TATA-Binding Protein: Difference between revisions
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{{ | [[Image:1tbp.png|left|200px|thumb|Crystal Structure of yeast TATA-binding protein, [[1tbp]]]] | ||
{{STRUCTURE_1tbp| PDB=1tbp | SIZE=300| SCENE=TATA-Binding_Protein/Cv/1 |right|CAPTION=TATA-binding protein, [[1tbp]] }} | |||
[[TATA-binding protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation. The images at the left and at the right correspond to one representative TBP, ''i.e.'' the crystal structure of yeast TATA-binding protein ([[1tbp]]). | |||
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== 3D Structures of TATA-binding protein == | |||
=== TBP === | |||
2z8u – TBP – Methanococcus janaschii | |||
1pcz – PwTBP - Pyrococcus woesei | |||
1vok – AtTBP - Arabidopsis thaliana | |||
1tbp – yTBP - yeast | |||
1mp9 – TBP – Sulfolobus acidocaldarius | |||
=== TBP+DNA TATA === | |||
1ytb - yTBP + DNA TATA | |||
1cdw - hTBP core domain+ DNA TATA - human | |||
1tgh - hTBP + DNA TATA | |||
1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne, 1qn3, 1qn4 - AtTBP + DNA TATA | |||
=== TBP+DNA TATA+TFIIA === | |||
1rm1 – yTBP+TFIIA chains+ DNA TATA | |||
1ytf - yTBP+TFIIA + DNA TATA | |||
1nh2 – yTBP C-terminal+TFIIA chains+ DNA TATA | |||
1nvp - hTBP C-terminal+ TFIIA chains+ DNA TATA | |||
1jfi - hTBP C-terminal+ TFIIA C2+ DNA TATA | |||
=== TBP+DNA TATA+TFIIB === | |||
1ngm - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA | |||
1tba – yTBP core domain+TAFII230 fragment - NMR | |||
1c9b - hTBP C-terminal+TFIIBC+adenovirus major late promoter | |||
1vol – AtTBP+hTFIIB+DNA TATA | |||
1ais, 1du3 - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA | |||
1tba – yTBP core domain+TAFII230 fragment - NMR | |||
== Additional information == | |||
This page has some initial scenes, but could use expansion and creation of new scenes. | This page has some initial scenes, but could use expansion and creation of new scenes. | ||
<applet load='1ytb' size='300' frame='true' align='right' caption='TATA-Binding Protein' scene='TATA-Binding_Protein/Tata-binding-protein/5' /> | <applet load='1ytb' size='300' frame='true' align='right' caption='TATA-Binding Protein' scene='TATA-Binding_Protein/Tata-binding-protein/5' /> | ||
Revision as of 13:47, 20 September 2010
TATA-binding protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation. The images at the left and at the right correspond to one representative TBP, i.e. the crystal structure of yeast TATA-binding protein (1tbp).
3D Structures of TATA-binding protein
TBP
2z8u – TBP – Methanococcus janaschii 1pcz – PwTBP - Pyrococcus woesei 1vok – AtTBP - Arabidopsis thaliana 1tbp – yTBP - yeast 1mp9 – TBP – Sulfolobus acidocaldarius
TBP+DNA TATA
1ytb - yTBP + DNA TATA 1cdw - hTBP core domain+ DNA TATA - human 1tgh - hTBP + DNA TATA 1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne, 1qn3, 1qn4 - AtTBP + DNA TATA
TBP+DNA TATA+TFIIA
1rm1 – yTBP+TFIIA chains+ DNA TATA 1ytf - yTBP+TFIIA + DNA TATA 1nh2 – yTBP C-terminal+TFIIA chains+ DNA TATA 1nvp - hTBP C-terminal+ TFIIA chains+ DNA TATA 1jfi - hTBP C-terminal+ TFIIA C2+ DNA TATA
TBP+DNA TATA+TFIIB
1ngm - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA 1tba – yTBP core domain+TAFII230 fragment - NMR 1c9b - hTBP C-terminal+TFIIBC+adenovirus major late promoter 1vol – AtTBP+hTFIIB+DNA TATA 1ais, 1du3 - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA
1tba – yTBP core domain+TAFII230 fragment - NMR
Additional information
This page has some initial scenes, but could use expansion and creation of new scenes.
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called the TATA box to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif
Proteopedia Page Contributors and Editors (what is this?)
Ala Jelani, Alexander Berchansky, David Canner, Michal Harel, Eran Hodis
