2w0j: Difference between revisions

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New page: '''Unreleased structure''' The entry 2w0j is ON HOLD until Paper Publication Authors: Lountos, G.T., Tropea, J.E., Zhang, D., Jobson, A.G., Pommier, Y., Shoemaker, R.H., Waugh, D.S. De...
 
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'''Unreleased structure'''
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[[Image:2w0j.jpg|left|200px]]


The entry 2w0j is ON HOLD until Paper Publication
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Authors: Lountos, G.T., Tropea, J.E., Zhang, D., Jobson, A.G., Pommier, Y., Shoemaker, R.H., Waugh, D.S.
===CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR===


Description: Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 10:53:18 2008''
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{{ABSTRACT_PUBMED_19177354}}
 
==About this Structure==
2W0J is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0J OCA].
 
==Reference==
<ref group="xtra">PMID:19177354</ref><ref group="xtra">PMID:17616632</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Jobson, A G.]]
[[Category: Lountos, G T.]]
[[Category: Pommier, Y.]]
[[Category: Shoemaker, R H.]]
[[Category: Tropea, J E.]]
[[Category: Waugh, D S.]]
[[Category: Zhang, D.]]
[[Category: Chk2 inhibitor]]
[[Category: Kinase]]
[[Category: Li-fraumeni syndrome]]
[[Category: Nucleotide-binding]]
[[Category: Oncology]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Structure-assisted drug design]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 12:37:34 2009''

Revision as of 10:37, 11 February 2009

File:2w0j.jpg

Template:STRUCTURE 2w0j

CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH NSC 109555, A SPECIFIC INHIBITOR

Template:ABSTRACT PUBMED 19177354

About this Structure

2W0J is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Lountos GT, Tropea JE, Zhang D, Jobson AG, Pommier Y, Shoemaker RH, Waugh DS. Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Sci. 2009 Jan;18(1):92-100. PMID:19177354 doi:10.1002/pro.16
  2. Jobson AG, Cardellina JH 2nd, Scudiero D, Kondapaka S, Zhang H, Kim H, Shoemaker R, Pommier Y. Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol. 2007 Oct;72(4):876-84. Epub 2007 Jul 6. PMID:17616632 doi:10.1124/mol.107.035832

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