1rlr: Difference between revisions
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New page: left|200px<br /><applet load="1rlr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rlr, resolution 2.5Å" /> '''STRUCTURE OF RIBONUCL... |
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[[Image:1rlr.jpg|left|200px]]<br /><applet load="1rlr" size=" | [[Image:1rlr.jpg|left|200px]]<br /><applet load="1rlr" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1rlr, resolution 2.5Å" /> | caption="1rlr, resolution 2.5Å" /> | ||
'''STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1'''<br /> | '''STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1'''<br /> | ||
==Overview== | ==Overview== | ||
Ribonucleotide reductase is the only enzyme that catalyses de novo | Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribonucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves five cysteins. Two redox-active cysteines are located at adjacent antiparallel strands in a new type of ten-stranded alpha/beta-barrel, and two others at the carboxyl end in a flexible arm. The fifth cysteine, in a loop in the centre of the barrel, is positioned to initiate the radical reaction. | ||
==About this Structure== | ==About this Structure== | ||
1RLR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] Full crystallographic information is available from [http:// | 1RLR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RLR OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: reductase (acting on ch2)]] | [[Category: reductase (acting on ch2)]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:15 2008'' | ||
