1rnd: Difference between revisions

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[[Image:1rnd.gif|left|200px]]<br /><applet load="1rnd" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1rnd.gif|left|200px]]<br /><applet load="1rnd" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1rnd, resolution 1.5Å" />

'''NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE'''<br />

==Overview==

Dinucleotides containing guanine, when soaked into crystals of bovine, pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This, finding has prompted a reexamination of three mononucleotide-RNase, complexes from this laboratory resulting in a re-interpretation of the, complex that involved a guanine mononucleotide.

Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.

==About this Structure==

1RND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SO4 and DGP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA].

1RND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=DGP:'>DGP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA].

==Reference==

Line 14:

[[Category: Pancreatic ribonuclease]]

[[Category: Single protein]]

[[Category: Aguilar, C.F.]]

[[Category: Aguilar, C F.]]

[[Category: Mills, A.]]

[[Category: Moss, D.S.]]

[[Category: Moss, D S.]]

[[Category: Palmer, R.A.]]

[[Category: Palmer, R A.]]

[[Category: Thomas, P.J.]]

[[Category: Thomas, P J.]]

[[Category: DGP]]

[[Category: SO4]]

[[Category: hydrolase(endoribonuclease)]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 01:43:~~45 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:38 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1rnd.gif|left|200px]]<br /><applet load="1rnd" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1rnd.gif|left|200px]]<br /><applet load="1rnd" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1rnd, resolution 1.5&Aring;" />
 '''NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE'''<br />
 ==Overview==
-Dinucleotides containing guanine, when soaked into crystals of bovine, pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This, finding has prompted a reexamination of three mononucleotide-RNase, complexes from this laboratory resulting in a re-interpretation of the, complex that involved a guanine mononucleotide.
+Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.
 ==About this Structure==
-RND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SO4 and DGP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA].
+RND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=DGP:'>DGP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Pancreatic ribonuclease]]
 [[Category: Single protein]]
-[[Category: Aguilar, C.F.]]
+[[Category: Aguilar, C F.]]
 [[Category: Mills, A.]]
-[[Category: Moss, D.S.]]
+[[Category: Moss, D S.]]
-[[Category: Palmer, R.A.]]
+[[Category: Palmer, R A.]]
-[[Category: Thomas, P.J.]]
+[[Category: Thomas, P J.]]
 [[Category: DGP]]
 [[Category: SO4]]
 [[Category: hydrolase(endoribonuclease)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:43:45 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:38 2008''