1rsy: Difference between revisions

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[[Image:1rsy.gif|left|200px]]<br /><applet load="1rsy" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1rsy.gif|left|200px]]<br /><applet load="1rsy" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1rsy, resolution 1.9Å" />

'''STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD'''<br />

==Overview==

C2 domains are regulatory sequence motifs that occur widely in nature., Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+, regulation of exocytosis, contains two C2 domains, the first of which acts, as a Ca2+ sensor. We now describe the three-dimensional structure of this, C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free, forms. The C2 polypeptide forms an eight-stranded beta sandwich, constructed around a conserved four-stranded motif designated as a C2 key., Ca2+ binds in a cup-shaped depression between two polypeptide loops, located at the N- and C-termini of the C2-key motif.

C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor. We now describe the three-dimensional structure of this C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide forms an eight-stranded beta sandwich constructed around a conserved four-stranded motif designated as a C2 key. Ca2+ binds in a cup-shaped depression between two polypeptide loops located at the N- and C-termini of the C2-key motif.

==About this Structure==

1RSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1RSY OCA].

1RSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSY OCA].

==Reference==

Line 13:

[[Category: Rattus norvegicus]]

[[Category: Single protein]]

[[Category: Sprang, S.R.]]

[[Category: Sprang, S R.]]

[[Category: Sutton, R.B.]]

[[Category: Sutton, R B.]]

[[Category: SO4]]

[[Category: calcium/phospholipid binding protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 01:51:~~10 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:54:09 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1rsy.gif|left|200px]]<br /><applet load="1rsy" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1rsy.gif|left|200px]]<br /><applet load="1rsy" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1rsy, resolution 1.9&Aring;" />
 '''STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD'''<br />
 ==Overview==
-C2 domains are regulatory sequence motifs that occur widely in nature., Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+, regulation of exocytosis, contains two C2 domains, the first of which acts, as a Ca2+ sensor. We now describe the three-dimensional structure of this, C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free, forms. The C2 polypeptide forms an eight-stranded beta sandwich, constructed around a conserved four-stranded motif designated as a C2 key., Ca2+ binds in a cup-shaped depression between two polypeptide loops, located at the N- and C-termini of the C2-key motif.
+C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor. We now describe the three-dimensional structure of this C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide forms an eight-stranded beta sandwich constructed around a conserved four-stranded motif designated as a C2 key. Ca2+ binds in a cup-shaped depression between two polypeptide loops located at the N- and C-termini of the C2-key motif.
 ==About this Structure==
-RSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RSY OCA].
+RSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSY OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Rattus norvegicus]]
 [[Category: Single protein]]
-[[Category: Sprang, S.R.]]
+[[Category: Sprang, S R.]]
-[[Category: Sutton, R.B.]]
+[[Category: Sutton, R B.]]
 [[Category: SO4]]
 [[Category: calcium/phospholipid binding protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:51:10 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:54:09 2008''