1cjx: Difference between revisions
New page: left|200px<br /> <applet load="1cjx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cjx, resolution 2.40Å" /> '''CRYSTAL STRUCTURE O... |
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==About this Structure== | ==About this Structure== | ||
1CJX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]] with FE2, EMC and ACT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.27 1.13.11.27]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CJX OCA]]. | 1CJX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]] with FE2, EMC and ACT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/4-hydroxyphenylpyruvate_dioxygenase 4-hydroxyphenylpyruvate dioxygenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.27 1.13.11.27]]. Structure known Active Sites: ASA, ASB, ASC and ASD. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CJX OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway., Serre L, Sailland A, Sy D, Boudec P, Rolland A, Pebay-Peyroula E, Cohen-Addad C, Structure. 1999 Aug 15;7(8):977-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10467142 10467142] | Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway., Serre L, Sailland A, Sy D, Boudec P, Rolland A, Pebay-Peyroula E, Cohen-Addad C, Structure. 1999 Aug 15;7(8):977-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10467142 10467142] | ||
[[Category: 4-hydroxyphenylpyruvate dioxygenase]] | |||
[[Category: Pseudomonas fluorescens]] | [[Category: Pseudomonas fluorescens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:44:06 2007'' | ||
Revision as of 11:39, 30 October 2007
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CRYSTAL STRUCTURE OF PSEUDOMONAS FLUORESCENS HPPD
Overview
BACKGROUND: In plants and photosynthetic bacteria, the tyrosine, degradation pathway is crucial because homogentisate, a tyrosine, degradation product, is a precursor for the biosynthesis of photosynthetic, pigments, such as quinones or tocophenols. Homogentisate biosynthesis, includes a decarboxylation step, a dioxygenation and a rearrangement of, the pyruvate sidechain. This complex reaction is carried out by a single, enzyme, the 4-hydroxyphenylpyruvate dioxygenase (HPPD), a non-heme iron, dependent enzyme that is active as a homotetramer in bacteria and as a, homodimer in plants. Moreover, in humans, a HPPD deficiency is found to be, related to tyrosinemia, a rare hereditary disorder of tyrosine catabolism., RESULTS: We report here the crystal structure of Pseudomonas fluorescens, ... [(full description)]
About this Structure
1CJX is a [Single protein] structure of sequence from [Pseudomonas fluorescens] with FE2, EMC and ACT as [ligands]. Active as [4-hydroxyphenylpyruvate dioxygenase], with EC number [1.13.11.27]. Structure known Active Sites: ASA, ASB, ASC and ASD. Full crystallographic information is available from [OCA].
Reference
Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway., Serre L, Sailland A, Sy D, Boudec P, Rolland A, Pebay-Peyroula E, Cohen-Addad C, Structure. 1999 Aug 15;7(8):977-88. PMID:10467142
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