1scm: Difference between revisions

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[[Image:1scm.gif|left|200px]]<br /><applet load="1scm" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1scm.gif|left|200px]]<br /><applet load="1scm" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1scm, resolution 2.8Å" />

'''STRUCTURE OF THE REGULATORY DOMAIN OF SCALLOP MYOSIN AT 2.8 ANGSTROMS RESOLUTION'''<br />

==Overview==

The regulatory domain of scallop myosin is a three-chain protein complex, that switches on this motor in response to Ca2+ binding. This domain has, been crystallized and the structure solved to 2.8 A resolution. Side-chain, interactions link the two light chains in tandem to adjacent segments of, the heavy chain bearing the IQ-sequence motif. The Ca(2+)-binding site is, a novel EF-hand motif on the essential light chain and is stabilized by, linkages involving the heavy chain and both light chains, accounting for, the requirement of all three chains for Ca2+ binding and regulation in the, intact myosin molecule.

The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. This domain has been crystallized and the structure solved to 2.8 A resolution. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca(2+)-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains, accounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule.

==About this Structure==

1SCM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1SCM OCA].

1SCM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCM OCA].

==Reference==

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[[Category: calcium-binding protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 02:16:~~35 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:00:11 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1scm.gif|left|200px]]<br /><applet load="1scm" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1scm.gif|left|200px]]<br /><applet load="1scm" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1scm, resolution 2.8&Aring;" />
 '''STRUCTURE OF THE REGULATORY DOMAIN OF SCALLOP MYOSIN AT 2.8 ANGSTROMS RESOLUTION'''<br />
 ==Overview==
-The regulatory domain of scallop myosin is a three-chain protein complex, that switches on this motor in response to Ca2+ binding. This domain has, been crystallized and the structure solved to 2.8 A resolution. Side-chain, interactions link the two light chains in tandem to adjacent segments of, the heavy chain bearing the IQ-sequence motif. The Ca(2+)-binding site is, a novel EF-hand motif on the essential light chain and is stabilized by, linkages involving the heavy chain and both light chains, accounting for, the requirement of all three chains for Ca2+ binding and regulation in the, intact myosin molecule.
+The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. This domain has been crystallized and the structure solved to 2.8 A resolution. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca(2+)-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains, accounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule.
 ==About this Structure==
-SCM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SCM OCA].
+SCM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCM OCA].
 ==Reference==
@@ Line 18: / Line 18: @@
 [[Category: calcium-binding protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:16:35 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:00:11 2008''