1sdb: Difference between revisions

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[[Image:1sdb.jpg|left|200px]]<br /><applet load="1sdb" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1sdb.jpg|left|200px]]<br /><applet load="1sdb" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1sdb, resolution 1.65Å" />

'''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''<br />

==Overview==

Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures, that it circulates and exerts its physiological functions in vivo as a, monomer. The crystal structure of monomeric porcine desB1-B2, despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has, been determined at 1.65 A resolution using the molecular replacement, method. A structural comparison between DesB1-2 DPI and 2Zn insulin, reveals that the conformation of DesB1-2 DPI is more similar to molecule I, than molecule II of 2Zn insulin. The remarkable conformational difference, between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30), insulin (DPI) indicates that the residue B25-Phe possesses great, flexibility and mobility.

Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.

==About this Structure==

1SDB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA].

1SDB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA].

==Reference==

Line 13:

[[Category: Protein complex]]

[[Category: Sus scrofa]]

[[Category: Diao, J.S.]]

[[Category: Diao, J S.]]

[[Category: Liang, D.C.]]

[[Category: Liang, D C.]]

[[Category: hormone]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 02:17:~~49 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:00:21 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1sdb.jpg|left|200px]]<br /><applet load="1sdb" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1sdb.jpg|left|200px]]<br /><applet load="1sdb" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1sdb, resolution 1.65&Aring;" />
 '''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''<br />
 ==Overview==
-Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures, that it circulates and exerts its physiological functions in vivo as a, monomer. The crystal structure of monomeric porcine desB1-B2, despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has, been determined at 1.65 A resolution using the molecular replacement, method. A structural comparison between DesB1-2 DPI and 2Zn insulin, reveals that the conformation of DesB1-2 DPI is more similar to molecule I, than molecule II of 2Zn insulin. The remarkable conformational difference, between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30), insulin (DPI) indicates that the residue B25-Phe possesses great, flexibility and mobility.
+Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.
 ==About this Structure==
-SDB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA].
+SDB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Protein complex]]
 [[Category: Sus scrofa]]
-[[Category: Diao, J.S.]]
+[[Category: Diao, J S.]]
-[[Category: Liang, D.C.]]
+[[Category: Liang, D C.]]
 [[Category: hormone]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:17:49 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:00:21 2008''