1skn: Difference between revisions

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[[Image:1skn.gif|left|200px]]<br /><applet load="1skn" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1skn.gif|left|200px]]<br /><applet load="1skn" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1skn, resolution 2.500Å" />

'''THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF'''<br />

==Overview==

The DNA-binding domain of Skn-1, a developmental transcription factor that, specifies mesoderm in C. elegans, is shown by X-ray crystallography to, have a novel fold in which a compact, monomeric, four-helix unit organizes, two DNA-contact elements. At the C-terminus, a helix extends from the, domain to occupy the major groove of DNA in a manner similar to bZip, proteins. Skn-1, however, lacks the leucine zipper found in all bZips., Additional contacts with the DNA are made by a short basic segment at the, N-terminus of the domain, reminiscent of the 'homeodomain arm'.

The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'.

==About this Structure==

1SKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with LDA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1SKN OCA].

1SKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with <scene name='pdbligand=LDA:'>LDA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKN OCA].

==Reference==

Line 14:

[[Category: Single protein]]

[[Category: Bowerman, B.]]

[[Category: Daughdrill, G.W.]]

[[Category: Daughdrill, G W.]]

[[Category: Matthews, B.W.]]

[[Category: Matthews, B W.]]

[[Category: Rupert, P.B.]]

[[Category: Rupert, P B.]]

[[Category: LDA]]

[[Category: complex (transcription factor/dna)]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 02:~~26:29 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:02:27 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1skn.gif|left|200px]]<br /><applet load="1skn" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1skn.gif|left|200px]]<br /><applet load="1skn" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1skn, resolution 2.500&Aring;" />
 '''THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF'''<br />
 ==Overview==
-The DNA-binding domain of Skn-1, a developmental transcription factor that, specifies mesoderm in C. elegans, is shown by X-ray crystallography to, have a novel fold in which a compact, monomeric, four-helix unit organizes, two DNA-contact elements. At the C-terminus, a helix extends from the, domain to occupy the major groove of DNA in a manner similar to bZip, proteins. Skn-1, however, lacks the leucine zipper found in all bZips., Additional contacts with the DNA are made by a short basic segment at the, N-terminus of the domain, reminiscent of the 'homeodomain arm'.
+The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'.
 ==About this Structure==
-SKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with LDA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SKN OCA].
+SKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans] with <scene name='pdbligand=LDA:'>LDA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKN OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Bowerman, B.]]
-[[Category: Daughdrill, G.W.]]
+[[Category: Daughdrill, G W.]]
-[[Category: Matthews, B.W.]]
+[[Category: Matthews, B W.]]
-[[Category: Rupert, P.B.]]
+[[Category: Rupert, P B.]]
 [[Category: LDA]]
 [[Category: complex (transcription factor/dna)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:26:29 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:02:27 2008''