1svb: Difference between revisions
New page: left|200px<br /><applet load="1svb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1svb, resolution 1.9Å" /> '''ENVELOPE GLYCOPROTEIN... |
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[[Image:1svb.gif|left|200px]]<br /><applet load="1svb" size=" | [[Image:1svb.gif|left|200px]]<br /><applet load="1svb" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1svb, resolution 1.9Å" /> | caption="1svb, resolution 1.9Å" /> | ||
'''ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS'''<br /> | '''ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS'''<br /> | ||
==Overview== | ==Overview== | ||
The crystallographically determined structure of a soluble fragment from | The crystallographically determined structure of a soluble fragment from the major envelope protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a direction that would be parallel to the viral membrane. Residues that influence binding of monoclonal antibodies lie on the outward-facing surface of the protein. The clustering of mutations that affect virulence in various flaviviruses indicates a possible receptor binding site and, together with other mutational and biochemical data, suggests a picture for the fusion-activating, conformational change triggered by low pH. | ||
==About this Structure== | ==About this Structure== | ||
1SVB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1SVB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Tick-borne encephalitis virus]] | [[Category: Tick-borne encephalitis virus]] | ||
[[Category: Harrison, S | [[Category: Harrison, S C.]] | ||
[[Category: Rey, F | [[Category: Rey, F A.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:05:32 2008'' | ||
Revision as of 13:05, 21 February 2008
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ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS
Overview
The crystallographically determined structure of a soluble fragment from the major envelope protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a direction that would be parallel to the viral membrane. Residues that influence binding of monoclonal antibodies lie on the outward-facing surface of the protein. The clustering of mutations that affect virulence in various flaviviruses indicates a possible receptor binding site and, together with other mutational and biochemical data, suggests a picture for the fusion-activating, conformational change triggered by low pH.
About this Structure
1SVB is a Single protein structure of sequence from Tick-borne encephalitis virus with NAG as ligand. Full crystallographic information is available from OCA.
Reference
The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:7753193
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