Induced fit: Difference between revisions
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[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classical example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] below. | |||
[[Image:Induced fit.gif]] | |||
==History of the concept== | |||
Induced fit was suggested by Koshland in 1958 <ref> DOI:10.1002/anie.199423751</ref>, providing an alternative to the lock-and-key binding model that Emil Fischer proposed in 1899 <ref>DOI:10.1002/cber.18940270364</ref>. | |||
==Interactive examples== | |||
<StructureSection load='' size='350' side='right' caption='' scene=''> | |||
In preparation. | |||
</StructureSection> | |||
==See Also== | ==See Also== | ||
*A morph of induced fit when [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Tamiflu_Binds_to_N1_by_Induced_Fit|Tamiflu binds to Neuraminidase]]. | *A morph of induced fit when [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Tamiflu_Binds_to_N1_by_Induced_Fit|Tamiflu binds to Neuraminidase]]. | ||
<references/> | |||
Revision as of 15:24, 13 April 2021
Induced fit describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classical example of induced fit is binding of glucose to hexokinase, depicted in a morph between 3o8m and 3o80 below.
History of the concept
Induced fit was suggested by Koshland in 1958 [1], providing an alternative to the lock-and-key binding model that Emil Fischer proposed in 1899 [2].
Interactive examples
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See Also
- A morph of induced fit when Tamiflu binds to Neuraminidase.
