Highest impact structures: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Eric Martz (talk | contribs) distinguished impact on scientific understanding from saving lives |
Eric Martz (talk | contribs) →See Also: new section on lives saved, including neuraminidase and tamiflu |
||
| Line 26: | Line 26: | ||
* '''2000(?) - Ribosome''': This structure surprised almost everyone by showing that peptidyl transferase is a ribozyme, rather than a protein enzyme. | * '''2000(?) - Ribosome''': This structure surprised almost everyone by showing that peptidyl transferase is a ribozyme, rather than a protein enzyme. | ||
==Structures Saving The Most Lives== | |||
Structures of the following molecules were used in [[Structure-based drug design|structure-based drug design]], and the resulting drugs have saved large numbers of lives. | |||
* Influenza virus neuraminidase structure was used in designing the neuraminidase inhibitors oseltamivir (Tamiflu®) and zanamivir (Relenza®). Roche, the manufacturer of Tamiflu, estimates that 50 million people have been treated with this drug<ref>[http://www.roche.com/med-cor-2007-04-26 Roche update on Tamiflu for pandemic influenza preparedness], Media Release, April 26, 2007.</ref>. Influenza kills hundreds of thousands of people annually<ref>[http://en.wikipedia.org/wiki/Influenza Influenza] in Wikipedia.</ref>, including 40,000 in the United States<ref>[http://aje.oxfordjournals.org/cgi/content/full/163/2/181 Mortality due to Influenza in the United States—An Annualized Regression Approach Using Multiple-Cause Mortality Data], J. Dushoff ''et al.'', Am. J. Epidemiol. 163:181-7, 2006. | |||
==See Also== | ==See Also== | ||
