User:Wayne Decatur/Sandbox: Difference between revisions
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{{STRUCTURE_1r9f | PDB= 1r9f | SCENE= }} | {{STRUCTURE_1r9f | PDB= 1r9f | SCENE= }} | ||
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{{STRUCTURE_1eve | PDB= 1eve | SCENE=Main_Page/E2020_in_ache_spinning/1 }} | |||
The collaborative, 3D encyclopedia of proteins and other molecules. | |||
===<span style="color:green">Green</span> links change the 3D image!=== | |||
<big>''Here's an excerpt from one of our pages ([[1eve]]):''</big> | |||
The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''. | |||
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Revision as of 06:25, 18 October 2008
Here is a schematic illustration of the two strands of this silencing RNA (siRNA):
5'-pCGUACGCGUCACGCGUACGUU-OH-3'
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3'-OH-UUGCAUGCGCACUGCGCAUGCp-5'
Template:STRUCTURE 1r9f
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| 1eve, resolution 2.50Å (default scene) | |||||||||||||
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| Ligands: | E20, NAG | ||||||||||||
| Activity: | Acetylcholinesterase, with EC number 3.1.1.7 | ||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
The collaborative, 3D encyclopedia of proteins and other molecules.
Green links change the 3D image!
Here's an excerpt from one of our pages (1eve):
The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from Torpedo california) complex shows that E2020 has a unique orientation along the active-site gorge, extending from the anionic subsite (W84) of the active site, at the bottom, to the peripheral anionic site (near W279), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only indirectly via solvent molecules.
