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| {{STRUCTURE_1r9f | PDB= 1r9f | SCENE= }} | | {{STRUCTURE_1r9f | PDB= 1r9f | SCENE= }} |
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| The line below this paragraph, containing "STRUCTURE_1eve", creates the "Structure Box" on the page.
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| {{STRUCTURE_1eve | PDB= 1eve | SCENE=Main_Page/E2020_in_ache_spinning/1 }}
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| The collaborative, 3D encyclopedia of proteins and other molecules.
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| ===<span style="color:green">Green</span> links change the 3D image!===
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| <big>''Here's an excerpt from one of our pages ([[1eve]]):''</big>
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| The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''.
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Revision as of 06:38, 18 October 2008
Here is a schematic illustration of the two strands of this silencing RNA (siRNA):
5'-pCGUACGCGUCACGCGUACGUU-OH-3'
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3'-OH-UUGCAUGCGCACUGCGCAUGCp-5'
Template:STRUCTURE 1r9f
