Pyruvate phosphate dikinase: Difference between revisions
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Dan Bolser (talk | contribs) wikified the ligand names (trying to understand the reaction) |
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You may also [https://carb.umbi.umd.edu/files/ppdk_release.mpg download] the full High Resolution video. | You may also [https://carb.umbi.umd.edu/files/ppdk_release.mpg download] the full High Resolution video. | ||
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'''Pyruvate phosphate dikinase''' (PPDK) is an enzyme that catalyzes the inter-conversion of adenosine triphosphate (ATP), phosphate (P<sub>i</sub>), and pyruvate with adenine monophosphate (AMP), pyrophosphate (PP<sub>i</sub>), and phosphoenolpyruvate (PEP) in the presence of Mg<sup>2+</sup> and K<sup>+</sup>/Na<sup>+</sup>. The three-step reversible reaction proceeds via phosphoenzyme and pyrophosphoenzyme intermediates with a histidine residue serving as the phosphocarrier: | '''Pyruvate phosphate dikinase''' (PPDK) is an enzyme that catalyzes the inter-conversion of [[adenosine triphosphate]] (ATP), [[phosphate]] (P<sub>i</sub>), and [[pyruvate]] with [[adenine monophosphate]] (AMP), [[pyrophosphate]] (PP<sub>i</sub>), and [[phosphoenolpyruvate]] (PEP) in the presence of Magnesium and potassium ions (Mg<sup>2+</sup> and K<sup>+</sup>/Na<sup>+</sup>). The three-step reversible reaction proceeds via phosphoenzyme and pyrophosphoenzyme intermediates with a histidine residue serving as the phosphocarrier: | ||
#PPDK-His + PEP ⇄ PPDK-His~PO<sub>3</sub> + pyruvate | #PPDK-His + PEP ⇄ PPDK-His~PO<sub>3</sub> + pyruvate | ||
