1tf2: Difference between revisions

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[[Image:1tf2.jpg|left|200px]]<br /><applet load="1tf2" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1tf2.jpg|left|200px]]<br /><applet load="1tf2" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1tf2, resolution 2.90Å" />

'''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis'''<br />

==Overview==

The ATPase SecA mediates the posttranslational translocation of a wide, range of polypeptide substrates through the SecY channel in the, cytoplasmic membrane of bacteria. We have determined the crystal structure, of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A, comparison with the previously determined structures of SecA reveals a, nucleotide-independent, large conformational change that opens a deep, groove similar to that in other proteins that interact with diverse, polypeptides. We propose that the open form of SecA represents an, activated state.

The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state.

==About this Structure==

1TF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with MG and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1TF2 OCA].

1TF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF2 OCA].

==Reference==

Line 13:

[[Category: Bacillus subtilis]]

[[Category: Single protein]]

[[Category: Jr., W.M.Clemons.]]

[[Category: Jr., W M.Clemons.]]

[[Category: Osborne, A.R.]]

[[Category: Osborne, A R.]]

[[Category: Rapoport, T.A.]]

[[Category: Rapoport, T A.]]

[[Category: ADP]]

[[Category: MG]]

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[[Category: translocation]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:12:56 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1tf2.jpg|left|200px]]<br /><applet load="1tf2" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1tf2.jpg|left|200px]]<br /><applet load="1tf2" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1tf2, resolution 2.90&Aring;" />
 '''Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis'''<br />
 ==Overview==
-The ATPase SecA mediates the posttranslational translocation of a wide, range of polypeptide substrates through the SecY channel in the, cytoplasmic membrane of bacteria. We have determined the crystal structure, of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A, comparison with the previously determined structures of SecA reveals a, nucleotide-independent, large conformational change that opens a deep, groove similar to that in other proteins that interact with diverse, polypeptides. We propose that the open form of SecA represents an, activated state.
+The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state.
 ==About this Structure==
-TF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with MG and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TF2 OCA].
+TF2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF2 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Bacillus subtilis]]
 [[Category: Single protein]]
-[[Category: Jr., W.M.Clemons.]]
+[[Category: Jr., W M.Clemons.]]
-[[Category: Osborne, A.R.]]
+[[Category: Osborne, A R.]]
-[[Category: Rapoport, T.A.]]
+[[Category: Rapoport, T A.]]
 [[Category: ADP]]
 [[Category: MG]]
@@ Line 23: / Line 23: @@
 [[Category: translocation]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:12:43 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:12:56 2008''