1thf: Difference between revisions

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[[Image:1thf.jpg|left|200px]]<br /><applet load="1thf" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1thf.jpg|left|200px]]<br /><applet load="1thf" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1thf, resolution 1.45Å" />

'''CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA'''<br />

==Overview==

The atomic structures of two proteins in the histidine biosynthesis, pathway consist of beta/alpha barrels with a twofold repeat pattern. It is, likely that these proteins evolved by twofold gene duplication and gene, fusion from a common half-barrel ancestor. These ancestral domains are not, visible as independent domains in the extant proteins but can be inferred, from a combination of sequence and structural analysis. The detection of, subdomain structures may be useful in efforts to search genome sequences, for functionally and structurally related proteins.

The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.

==About this Structure==

1THF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1THF OCA].

1THF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THF OCA].

==Reference==

Line 13:

[[Category: Single protein]]

[[Category: Thermotoga maritima]]

[[Category: Lang, D.A.]]

[[Category: Lang, D A.]]

[[Category: Wilmanns, M.]]

[[Category: PO4]]

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[[Category: tim-barrel]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 03:15:~~58 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:39 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1thf.jpg|left|200px]]<br /><applet load="1thf" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1thf.jpg|left|200px]]<br /><applet load="1thf" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1thf, resolution 1.45&Aring;" />
 '''CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA'''<br />
 ==Overview==
-The atomic structures of two proteins in the histidine biosynthesis, pathway consist of beta/alpha barrels with a twofold repeat pattern. It is, likely that these proteins evolved by twofold gene duplication and gene, fusion from a common half-barrel ancestor. These ancestral domains are not, visible as independent domains in the extant proteins but can be inferred, from a combination of sequence and structural analysis. The detection of, subdomain structures may be useful in efforts to search genome sequences, for functionally and structurally related proteins.
+The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.
 ==About this Structure==
-THF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1THF OCA].
+THF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THF OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Thermotoga maritima]]
-[[Category: Lang, D.A.]]
+[[Category: Lang, D A.]]
 [[Category: Wilmanns, M.]]
 [[Category: PO4]]
@@ Line 22: / Line 22: @@
 [[Category: tim-barrel]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:15:58 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:39 2008''