1tif: Difference between revisions

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[[Image:1tif.gif|left|200px]]<br /><applet load="1tif" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1tif.gif|left|200px]]<br /><applet load="1tif" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1tif, resolution 1.8Å" />

'''TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN'''<br />

==Overview==

The structures of the two domains of translational initiation factor IF3, from Bacillus stearothermophilus have been solved by X-ray crystallography, using single wavelength anomalous scattering and multiwavelength anomalous, diffraction. Each of the two domains has an alpha/beta topology, with an, exposed beta-sheet that is reminiscent of several ribosomal and other RNA, binding proteins. An alpha-helix that protrudes out from the body of the, N-terminal domain towards the C-terminal domain suggests that IF3 consists, of two RNA binding domains connected by an alpha-helix and that it may, bridge two regions of the ribosome. This represents the first high, resolution structural information on a translational initiation factor.

The structures of the two domains of translational initiation factor IF3 from Bacillus stearothermophilus have been solved by X-ray crystallography using single wavelength anomalous scattering and multiwavelength anomalous diffraction. Each of the two domains has an alpha/beta topology, with an exposed beta-sheet that is reminiscent of several ribosomal and other RNA binding proteins. An alpha-helix that protrudes out from the body of the N-terminal domain towards the C-terminal domain suggests that IF3 consists of two RNA binding domains connected by an alpha-helix and that it may bridge two regions of the ribosome. This represents the first high resolution structural information on a translational initiation factor.

==About this Structure==

1TIF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with PBM and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1TIF OCA].

1TIF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with <scene name='pdbligand=PBM:'>PBM</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIF OCA].

==Reference==

Line 20:

[[Category: if3 n-terminal domain]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 03:17:~~34 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:49 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1tif.gif|left|200px]]<br /><applet load="1tif" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1tif.gif|left|200px]]<br /><applet load="1tif" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1tif, resolution 1.8&Aring;" />
 '''TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN'''<br />
 ==Overview==
-The structures of the two domains of translational initiation factor IF3, from Bacillus stearothermophilus have been solved by X-ray crystallography, using single wavelength anomalous scattering and multiwavelength anomalous, diffraction. Each of the two domains has an alpha/beta topology, with an, exposed beta-sheet that is reminiscent of several ribosomal and other RNA, binding proteins. An alpha-helix that protrudes out from the body of the, N-terminal domain towards the C-terminal domain suggests that IF3 consists, of two RNA binding domains connected by an alpha-helix and that it may, bridge two regions of the ribosome. This represents the first high, resolution structural information on a translational initiation factor.
+The structures of the two domains of translational initiation factor IF3 from Bacillus stearothermophilus have been solved by X-ray crystallography using single wavelength anomalous scattering and multiwavelength anomalous diffraction. Each of the two domains has an alpha/beta topology, with an exposed beta-sheet that is reminiscent of several ribosomal and other RNA binding proteins. An alpha-helix that protrudes out from the body of the N-terminal domain towards the C-terminal domain suggests that IF3 consists of two RNA binding domains connected by an alpha-helix and that it may bridge two regions of the ribosome. This represents the first high resolution structural information on a translational initiation factor.
 ==About this Structure==
-TIF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with PBM and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TIF OCA].
+TIF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with <scene name='pdbligand=PBM:'>PBM</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIF OCA].
 ==Reference==
@@ Line 20: / Line 20: @@
 [[Category: if3 n-terminal domain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:17:34 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:49 2008''