1tig: Difference between revisions
New page: left|200px<br /><applet load="1tig" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tig, resolution 2.0Å" /> '''TRANSLATION INITIATIO... |
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[[Image:1tig.gif|left|200px]]<br /><applet load="1tig" size=" | [[Image:1tig.gif|left|200px]]<br /><applet load="1tig" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1tig, resolution 2.0Å" /> | caption="1tig, resolution 2.0Å" /> | ||
'''TRANSLATION INITIATION FACTOR 3 C-TERMINAL DOMAIN'''<br /> | '''TRANSLATION INITIATION FACTOR 3 C-TERMINAL DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
The structures of the two domains of translational initiation factor IF3 | The structures of the two domains of translational initiation factor IF3 from Bacillus stearothermophilus have been solved by X-ray crystallography using single wavelength anomalous scattering and multiwavelength anomalous diffraction. Each of the two domains has an alpha/beta topology, with an exposed beta-sheet that is reminiscent of several ribosomal and other RNA binding proteins. An alpha-helix that protrudes out from the body of the N-terminal domain towards the C-terminal domain suggests that IF3 consists of two RNA binding domains connected by an alpha-helix and that it may bridge two regions of the ribosome. This represents the first high resolution structural information on a translational initiation factor. | ||
==About this Structure== | ==About this Structure== | ||
1TIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http:// | 1TIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIG OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: if3 c-terminal domain]] | [[Category: if3 c-terminal domain]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:49 2008'' | ||
Revision as of 13:13, 21 February 2008
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TRANSLATION INITIATION FACTOR 3 C-TERMINAL DOMAIN
Overview
The structures of the two domains of translational initiation factor IF3 from Bacillus stearothermophilus have been solved by X-ray crystallography using single wavelength anomalous scattering and multiwavelength anomalous diffraction. Each of the two domains has an alpha/beta topology, with an exposed beta-sheet that is reminiscent of several ribosomal and other RNA binding proteins. An alpha-helix that protrudes out from the body of the N-terminal domain towards the C-terminal domain suggests that IF3 consists of two RNA binding domains connected by an alpha-helix and that it may bridge two regions of the ribosome. This represents the first high resolution structural information on a translational initiation factor.
About this Structure
1TIG is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix., Biou V, Shu F, Ramakrishnan V, EMBO J. 1995 Aug 15;14(16):4056-64. PMID:7664745
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