1w6t: Difference between revisions
New page: left|200px<br /> <applet load="1w6t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w6t, resolution 2.10Å" /> '''CRYSTAL STRUCTURE O... |
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==About this Structure== | ==About this Structure== | ||
1W6T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with MG and 2PE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.11 4.2.1.11]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6T OCA]]. | 1W6T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with MG and 2PE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Phosphopyruvate_hydratase Phosphopyruvate hydratase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.11 4.2.1.11]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6T OCA]]. | ||
==Reference== | ==Reference== | ||
Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites., Ehinger S, Schubert WD, Bergmann S, Hammerschmidt S, Heinz DW, J Mol Biol. 2004 Oct 29;343(4):997-1005. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15476816 15476816] | Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites., Ehinger S, Schubert WD, Bergmann S, Hammerschmidt S, Heinz DW, J Mol Biol. 2004 Oct 29;343(4):997-1005. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15476816 15476816] | ||
[[Category: Phosphopyruvate hydratase]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
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[[Category: surface protein]] | [[Category: surface protein]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:50:44 2007'' | ||
Revision as of 11:46, 30 October 2007
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CRYSTAL STRUCTURE OF OCTAMERIC ENOLASE FROM STREPTOCOCCUS PNEUMONIAE
Overview
Alpha-enolases are ubiquitous cytoplasmic, glycolytic enzymes. In, pathogenic bacteria, alpha-enolase doubles as a surface-displayed, plasmin(ogen)-binder supporting virulence. The plasmin(ogen)-binding site, was initially traced to the two C-terminal lysine residues. More recently, an internal nine-amino acid motif comprising residues 248 to 256 was, identified with this function. We report the crystal structure of, alpha-enolase from Streptococcus pneumoniae at 2.0A resolution, the first, structure both of a plasminogen-binding and of an octameric alpha-enolase., While the dimer is structurally similar to other alpha-enolases, the, octamer places the C-terminal lysine residues in an inaccessible, inter-dimer groove restricting the C-terminal lysine residues to a role in, folding and ... [(full description)]
About this Structure
1W6T is a [Single protein] structure of sequence from [Streptococcus pneumoniae] with MG and 2PE as [ligands]. Active as [Phosphopyruvate hydratase], with EC number [4.2.1.11]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites., Ehinger S, Schubert WD, Bergmann S, Hammerschmidt S, Heinz DW, J Mol Biol. 2004 Oct 29;343(4):997-1005. PMID:15476816
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