1tnd: Difference between revisions
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New page: left|200px<br /><applet load="1tnd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tnd, resolution 2.2Å" /> '''THE 2.2 ANGSTROMS CRY... |
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[[Image:1tnd.gif|left|200px]]<br /><applet load="1tnd" size=" | [[Image:1tnd.gif|left|200px]]<br /><applet load="1tnd" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1tnd, resolution 2.2Å" /> | caption="1tnd, resolution 2.2Å" /> | ||
'''THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S'''<br /> | '''THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S'''<br /> | ||
==Overview== | ==Overview== | ||
The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP | The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data. | ||
==About this Structure== | ==About this Structure== | ||
1TND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with MG, CAC and GSP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1TND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CAC:'>CAC</scene> and <scene name='pdbligand=GSP:'>GSP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TND OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hamm, H | [[Category: Hamm, H E.]] | ||
[[Category: Noel, J | [[Category: Noel, J P.]] | ||
[[Category: Sigler, P | [[Category: Sigler, P B.]] | ||
[[Category: CAC]] | [[Category: CAC]] | ||
[[Category: GSP]] | [[Category: GSP]] | ||
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[[Category: binding protein(gtp)]] | [[Category: binding protein(gtp)]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:22 2008'' | ||
