1u9k: Difference between revisions

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[[Image:1u9k.jpg|left|200px]]<br /><applet load="1u9k" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1u9k.jpg|left|200px]]<br /><applet load="1u9k" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1u9k, resolution 1.76Å" />

'''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76'''<br />

==Overview==

Triggering receptor expressed on myeloid cells (TREM) 1 is an activating, receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1, stimulation activates neutrophils and monocytes and induces the secretion, of pro-inflammatory molecules, which amplifies the Toll-like, receptor-initiated responses to invading pathogens. In addition, TREM-1, mediates the septic shock pathway, and thus represents a potential, therapeutic target. We report the crystal structure of the mouse TREM-1, extracellular domain at 1.76A resolution. The mouse extracellular domain, is monomeric, consistent with our previous human TREM-1 structure, and, strongly supports the contention that the globular TREM-1 head is a, monomer contrary to proposals of a symmetric dimer.

Triggering receptor expressed on myeloid cells (TREM) 1 is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer.

==About this Structure==

1U9K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1U9K OCA].

1U9K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9K OCA].

==Reference==

Line 13:

[[Category: Mus musculus]]

[[Category: Single protein]]

[[Category: Debler, E.W.]]

[[Category: Debler, E W.]]

[[Category: Kelker, M.S.]]

[[Category: Kelker, M S.]]

[[Category: Wilson, I.A.]]

[[Category: Wilson, I A.]]

[[Category: ZN]]

[[Category: activating receptors]]

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[[Category: trem-1]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 03:56:~~38 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:22:11 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1u9k.jpg|left|200px]]<br /><applet load="1u9k" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1u9k.jpg|left|200px]]<br /><applet load="1u9k" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1u9k, resolution 1.76&Aring;" />
 '''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76'''<br />
 ==Overview==
-Triggering receptor expressed on myeloid cells (TREM) 1 is an activating, receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1, stimulation activates neutrophils and monocytes and induces the secretion, of pro-inflammatory molecules, which amplifies the Toll-like, receptor-initiated responses to invading pathogens. In addition, TREM-1, mediates the septic shock pathway, and thus represents a potential, therapeutic target. We report the crystal structure of the mouse TREM-1, extracellular domain at 1.76A resolution. The mouse extracellular domain, is monomeric, consistent with our previous human TREM-1 structure, and, strongly supports the contention that the globular TREM-1 head is a, monomer contrary to proposals of a symmetric dimer.
+Triggering receptor expressed on myeloid cells (TREM) 1 is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer.
 ==About this Structure==
-U9K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1U9K OCA].
+U9K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9K OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Mus musculus]]
 [[Category: Single protein]]
-[[Category: Debler, E.W.]]
+[[Category: Debler, E W.]]
-[[Category: Kelker, M.S.]]
+[[Category: Kelker, M S.]]
-[[Category: Wilson, I.A.]]
+[[Category: Wilson, I A.]]
 [[Category: ZN]]
 [[Category: activating receptors]]
@@ Line 22: / Line 22: @@
 [[Category: trem-1]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:56:38 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:22:11 2008''