Proteopedia:Main page develop: Difference between revisions
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<div style="font-size:175%;">Welcome to Proteopedia,</div> | |||
<div>The free, collaborative 3D encyclopedia</div> | |||
<div>of proteins & other molecules</div> | |||
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[[About]] [[Editing]] [[Help]] [[Contents]] [[Topic Pages]] [[What's New]] | |||
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|<div>This week's featured article</div> | |||
|<applet load='1eve' size='300' frame='true' align='right' caption='Insert caption here' scene='Main_Page/E2020_in_ache_spinning/1'/> | |||
|The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/12'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/6'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/4'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/7'>indirectly via solvent molecules</scene>'''. | |||
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<big>Welcome to Proteopedia,</big> | <big>Welcome to Proteopedia,</big> | ||
