1uhn: Difference between revisions

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[[Image:1uhn.jpg|left|200px]]<br /><applet load="1uhn" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1uhn.jpg|left|200px]]<br /><applet load="1uhn" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1uhn, resolution 2.1Å" />

'''The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana'''<br />

==Overview==

Arabidopsis thaliana calcineurin B-like protein (AtCBL2) is a member of a, recently identified family of calcineurin B-like calcium-binding proteins, in A. thaliana. The crystal structure of AtCBL2 has been determined at 2.1, A resolution. The protein forms a compact alpha-helical structure with two, pairs of EF-hand motifs. The structure is similar in overall folding, topology to the structures of calcineurin B and neuronal calcium sensor 1, but differs significantly in local conformation. The two calcium ions are, coordinated in the first and fourth EF-hand motifs, whereas the second and, third EF-hand motifs are maintained in the open form by internal hydrogen, bonding without coordination of calcium ions. Both a possible site and a, possible mechanism for the target binding to AtCBL2 are discussed based on, the three-dimensional structure.

Arabidopsis thaliana calcineurin B-like protein (AtCBL2) is a member of a recently identified family of calcineurin B-like calcium-binding proteins in A. thaliana. The crystal structure of AtCBL2 has been determined at 2.1 A resolution. The protein forms a compact alpha-helical structure with two pairs of EF-hand motifs. The structure is similar in overall folding topology to the structures of calcineurin B and neuronal calcium sensor 1, but differs significantly in local conformation. The two calcium ions are coordinated in the first and fourth EF-hand motifs, whereas the second and third EF-hand motifs are maintained in the open form by internal hydrogen bonding without coordination of calcium ions. Both a possible site and a possible mechanism for the target binding to AtCBL2 are discussed based on the three-dimensional structure.

==About this Structure==

1UHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1UHN OCA].

1UHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHN OCA].

==Reference==

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[[Category: calcium binding protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 04:08:~~13 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:24:37 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1uhn.jpg|left|200px]]<br /><applet load="1uhn" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1uhn.jpg|left|200px]]<br /><applet load="1uhn" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1uhn, resolution 2.1&Aring;" />
 '''The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana'''<br />
 ==Overview==
-Arabidopsis thaliana calcineurin B-like protein (AtCBL2) is a member of a, recently identified family of calcineurin B-like calcium-binding proteins, in A. thaliana. The crystal structure of AtCBL2 has been determined at 2.1, A resolution. The protein forms a compact alpha-helical structure with two, pairs of EF-hand motifs. The structure is similar in overall folding, topology to the structures of calcineurin B and neuronal calcium sensor 1, but differs significantly in local conformation. The two calcium ions are, coordinated in the first and fourth EF-hand motifs, whereas the second and, third EF-hand motifs are maintained in the open form by internal hydrogen, bonding without coordination of calcium ions. Both a possible site and a, possible mechanism for the target binding to AtCBL2 are discussed based on, the three-dimensional structure.
+Arabidopsis thaliana calcineurin B-like protein (AtCBL2) is a member of a recently identified family of calcineurin B-like calcium-binding proteins in A. thaliana. The crystal structure of AtCBL2 has been determined at 2.1 A resolution. The protein forms a compact alpha-helical structure with two pairs of EF-hand motifs. The structure is similar in overall folding topology to the structures of calcineurin B and neuronal calcium sensor 1, but differs significantly in local conformation. The two calcium ions are coordinated in the first and fourth EF-hand motifs, whereas the second and third EF-hand motifs are maintained in the open form by internal hydrogen bonding without coordination of calcium ions. Both a possible site and a possible mechanism for the target binding to AtCBL2 are discussed based on the three-dimensional structure.
 ==About this Structure==
-UHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UHN OCA].
+UHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHN OCA].
 ==Reference==
@@ Line 23: / Line 23: @@
 [[Category: calcium binding protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:08:13 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:24:37 2008''