1ul2: Difference between revisions
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New page: left|200px<br /><applet load="1ul2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ul2" /> '''Solution Conformation of alpha-Conotoxin GIC... |
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[[Image:1ul2.jpg|left|200px]]<br /><applet load="1ul2" size=" | [[Image:1ul2.jpg|left|200px]]<br /><applet load="1ul2" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''Solution Conformation of alpha-Conotoxin GIC'''<br /> | '''Solution Conformation of alpha-Conotoxin GIC'''<br /> | ||
==Overview== | ==Overview== | ||
Alpha-conotoxin GIC is a 16-residue peptide isolated from the venom of the | Alpha-conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. Alpha-conotoxin GIC potently blocks the alpha3beta2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [McIntosh, Dowell, Watkins, Garrett, Yoshikami, and Olivera (2002) J. Biol. Chem. 277, 33610-33615]. We have now determined the three-dimensional solution structure of alpha-conotoxin GIC by NMR spectroscopy. The structure of alpha-conotoxin GIC is well defined with backbone and heavy atom root mean square deviations (residues 2-16) of 0.53 A and 0.96 A respectively. Structure and surface comparison of alpha-conotoxin GIC with the other alpha4/7 subfamily conotoxins reveals unique structural aspects of alpha-conotoxin GIC. In particular, the structural comparison between alpha-conotoxins GIC and MII indicates molecular features that may confer their similar receptor specificity profile, as well as those that provide the unique binding characteristics of alpha-conotoxin GIC. | ||
==About this Structure== | ==About this Structure== | ||
1UL2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with NH2 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1UL2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL2 OCA]. | ||
==Reference== | ==Reference== | ||
Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem J. 2004 Jun 1;380(Pt 2):347-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14992691 14992691] | Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem J. 2004 Jun 1;380(Pt 2):347-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14992691 14992691] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chi, S | [[Category: Chi, S W.]] | ||
[[Category: Han, K | [[Category: Han, K H.]] | ||
[[Category: Kim, D | [[Category: Kim, D H.]] | ||
[[Category: McIntosh, J | [[Category: McIntosh, J M.]] | ||
[[Category: Olivera, B | [[Category: Olivera, B M.]] | ||
[[Category: NH2]] | [[Category: NH2]] | ||
[[Category: alpha-helix]] | [[Category: alpha-helix]] | ||
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[[Category: two disulfide bonds]] | [[Category: two disulfide bonds]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:25:42 2008'' | ||
