OhrR: Difference between revisions
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Generating vacuum electrostatics with PyMol shows significant positive charge distribution in the DNA-binding domain. The analysis also revealed a negative pocket in the center of the dimerization interface. The publishes of these OhrR structures have proposed that this region (which also included conserved hydrophobic residues) may serve as a binding pocket for hydroperoxide species. Positive charges have been colored in blue. Negative charges are indicated by red. The image below shows side-by-side views acquired from PyMol without changing the orientation of the molecule between images. | Generating vacuum electrostatics with PyMol shows significant positive charge distribution in the DNA-binding domain. The analysis also revealed a negative pocket in the center of the dimerization interface. The publishes of these OhrR structures have proposed that this region (which also included conserved hydrophobic residues) may serve as a binding pocket for hydroperoxide species. Positive charges have been colored in blue. Negative charges are indicated by red. The image below shows side-by-side views acquired from PyMol without changing the orientation of the molecule between images. | ||
[[Image:ElectrostaticsOhrR.png| | [[Image:ElectrostaticsOhrR.png|center|600px]]<br /> | ||
==Transcription Regulation as a Mechanism to Evade Reactive Oxygen Species (ROS)== | ==Transcription Regulation as a Mechanism to Evade Reactive Oxygen Species (ROS)== | ||
