User:Max Lein/Sandbox: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
The PDB 1gpa contains 4 chains of the 'A' form of glycogen phosphorylase. Each subunit contains a phosphate group bound to Ser14, sulfate groups bound to two effector sites (sulfate acts as a mimic of phosphate groups), and the cofactor pyridoxal-5'-phosphate bound to K681. | The PDB 1gpa contains 4 chains of the 'A' form of glycogen phosphorylase. Each subunit contains a phosphate group bound to Ser14, sulfate groups bound to two effector sites (sulfate acts as a mimic of phosphate groups), and the cofactor pyridoxal-5'-phosphate bound to K681. See the links section at the end of this page for links to more structural information on glycogen phosphorylase. | ||
==Reaction== | ==Reaction== | ||
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In addition, the 'A' and 'B' forms can be regulated futher by small molecules in the cell. This allows individual cells to ignore the hormonal signal if they already have enough available energy (at high concentrations of glucose derivatives or ATP, designated as the 'R' state), or activate GP without a hormonal signal when energy for the individual cell is needed (high concentrations of AMP, designated as the 'T' state). | In addition, the 'A' and 'B' forms can be regulated futher by small molecules in the cell. This allows individual cells to ignore the hormonal signal if they already have enough available energy (at high concentrations of glucose derivatives or ATP, designated as the 'R' state), or activate GP without a hormonal signal when energy for the individual cell is needed (high concentrations of AMP, designated as the 'T' state). | ||
==Links== | |||
1GPA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Additional information on 1GPA is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb24_1.html Glycogen Phosphorylase] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GPA OCA]. | 1GPA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Additional information on 1GPA is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb24_1.html Glycogen Phosphorylase] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GPA OCA]. | ||
