Doppel: Difference between revisions
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Kurt Giles (talk | contribs) New page: Doppel (Dpl), named for '''''do'''wnstream '''p'''rion '''p'''rotein like''<ref>1</ref>, is a homolog of the prion protein (PrP). It is a cell surface glycoprotein. ==Structure of Dpl... |
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{{STRUCTURE_1lg4 | PDB=1lg4 | SCENE= }} | {{STRUCTURE_1lg4 | PDB=1lg4 | SCENE= }} | ||
Dpl has the same fold as PrP, with three alpha helices and two short beta strands, however it differs in that the third helix has a significant kink in it and it also contains two disulphide bonds. | Dpl has the same fold as PrP, with three alpha helices and two short beta strands, however it differs in that the third helix has a significant kink in it and it also contains two disulphide bonds. | ||
=Related structures= | |||
* [[1z65]] Mouse Dpl residues 1-30 | |||
* [[1lg4]] Human Dpl residues 24-152 | |||
* [[1i17]] Mouse Dpl residues 51-157 | |||
* [[1h0l]] Human PrP residues 121-230, with an additional disulphide bond analogous to the homolog [[Doppel]] | |||
=References= | =References= | ||
{{Reflist}} | |||
Moore ''et al.'' (1999) Ataxia in Prion Protein (PrP)-deficient Mice is | Moore ''et al.'' (1999) Ataxia in Prion Protein (PrP)-deficient Mice is | ||
Associated with Upregulation of the Novel PrP-like | Associated with Upregulation of the Novel PrP-like | ||
Protein Doppel ''J. Mol. Biol.'' '''292''', 797-817 | Protein Doppel ''J. Mol. Biol.'' '''292''', 797-817 </reference> | ||
Zahn R. et al. (2003) NMR structure of a variant human prion protein with two disulfide bridges'' J. Mol. Biol.'' '''326''', 225-34. | |||
