User:Youngsen Jeng: Difference between revisions
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Structural stabilization of Glutamine Synthetase by divalent cations, especially by the n1 ion<'''Insert wiki here'''>, has been ascribed to the attraction of their positive charges to the negative charges of glutamate and ATP and of their ligands<'''Insert wiki here'''> (Liaw et al., 1993~). | Structural stabilization of Glutamine Synthetase by divalent cations, especially by the n1 ion<'''Insert wiki here'''>, has been ascribed to the attraction of their positive charges to the negative charges of glutamate and ATP and of their ligands<'''Insert wiki here'''> (Liaw et al., 1993~). | ||
The structure of the dodecamer exposes several alpha loops which are important in stabilizing quaternary structure of Glutamine Synthetase. One beta loop consists of hydrophilic residues 156-173,<insert wiki> projects into the central channel of the dodecamer. Another beta loop is the adenylylation loop<insert wiki>, so called because it contains tyrosyine residue 397 which is covalently modified by addition of AMP. The amino group of glutamate shifts the Asn-264 loop, helping Ser-53P, on the Asp-50P loop, to stabilize the flap<insert wiki>. | |||
=References= | =References= | ||
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