User:Youngsen Jeng: Difference between revisions

Line 22:

Structural stabilization of Glutamine Synthetase by divalent cations, especially by the n1 ion<'''Insert wiki here'''>, has been ascribed to the attraction of their positive charges to the negative charges of glutamate and ATP and of their ligands<'''Insert wiki here'''> (Liaw et al., 1993~).

The structure of the dodecamer exposes several alpha loops which are important in stabilizing quaternary structure of Glutamine Synthetase. One beta loop consists of <scene name='User:Youngsen_Jeng/Beta_loop_156-173/1'>hydrophilic residues</scene> 156-173, projects into the<scene name='User:Youngsen_Jeng/Beta_loop_projecting/1'>central channel</scene> of the dodecamer. Another beta loop is the <scene name='User:Youngsen_Jeng/Beta_loop_with_tyr_397/1'>adenylation loop</scene>, so called because it contains tyrosyine residue 397 which is covalently modified by addition of AMP. The amino group of glutamate shifts the Asn-264 loop, helping Ser-53P, on the Asp-50P loop, to stabilize the flap<insert wiki>.

The structure of the dodecamer exposes several alpha loops which are important in stabilizing quaternary structure of Glutamine Synthetase. One beta loop consists of <scene name='User:Youngsen_Jeng/Beta_loop_156-173/1'>hydrophilic residues</scene> 156-173, projects into the <scene name='User:Youngsen_Jeng/Beta_loop_projecting/1'>central channel</scene> of the dodecamer. Another beta loop is the <scene name='User:Youngsen_Jeng/Beta_loop_with_tyr_397/1'>adenylation loop</scene>, so called because it contains tyrosyine residue 397 which is covalently modified by addition of AMP. The amino group of glutamate shifts the Asn-264 loop, helping Ser-53P, on the Asp-50P loop, to stabilize the flap<insert wiki>.

=References=

User:Youngsen Jeng: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 22: / Line 22: @@
 Structural stabilization of Glutamine Synthetase by divalent cations, especially by the n1 ion<'''Insert wiki here'''>, has been ascribed to the attraction of their positive charges to the negative charges of glutamate and ATP and of their ligands<'''Insert wiki here'''> (Liaw et al., 1993~).
-The structure of the dodecamer exposes several alpha loops which are important in stabilizing quaternary structure of Glutamine Synthetase. One beta loop consists of <scene name='User:Youngsen_Jeng/Beta_loop_156-173/1'>hydrophilic residues</scene> 156-173, projects into the<scene name='User:Youngsen_Jeng/Beta_loop_projecting/1'>central channel</scene> of the dodecamer. Another beta loop is the <scene name='User:Youngsen_Jeng/Beta_loop_with_tyr_397/1'>adenylation loop</scene>, so called because it contains tyrosyine residue 397 which is covalently modified by addition of AMP. The amino group of glutamate shifts the Asn-264 loop, helping Ser-53P, on the Asp-50P loop, to stabilize the flap<insert wiki>.
+The structure of the dodecamer exposes several alpha loops which are important in stabilizing quaternary structure of Glutamine Synthetase. One beta loop consists of <scene name='User:Youngsen_Jeng/Beta_loop_156-173/1'>hydrophilic residues</scene> 156-173, projects into the <scene name='User:Youngsen_Jeng/Beta_loop_projecting/1'>central channel</scene> of the dodecamer. Another beta loop is the <scene name='User:Youngsen_Jeng/Beta_loop_with_tyr_397/1'>adenylation loop</scene>, so called because it contains tyrosyine residue 397 which is covalently modified by addition of AMP. The amino group of glutamate shifts the Asn-264 loop, helping Ser-53P, on the Asp-50P loop, to stabilize the flap<insert wiki>.
 =References=
 <references/>