1vqh: Difference between revisions

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[[Image:1vqh.jpg|left|200px]]<br /><applet load="1vqh" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1vqh.jpg|left|200px]]<br /><applet load="1vqh" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1vqh, resolution 1.8Å" />

'''GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY MET 47 (I47M)'''<br />

==Overview==

The problem of rationally engineering protein molecules can be simplified, where effects of mutations on protein function are additive. Crystal, structures of single and double mutants in the hydrophobic core of gene V, protein indicate that structural and functional effects of core mutations, are additive when the regions structurally influenced by the mutations do, not substantially overlap. These regions of influence can provide a simple, basis for identifying sets of mutations that will show additive effects.

The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects.

==About this Structure==

1VQH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacteriophage_f1 Bacteriophage f1]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1VQH OCA].

1VQH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacteriophage_f1 Bacteriophage f1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQH OCA].

==Reference==

Line 13:

[[Category: Bacteriophage f1]]

[[Category: Single protein]]

[[Category: Skinner, M.M.]]

[[Category: Skinner, M M.]]

[[Category: Terwilliger, T.C.]]

[[Category: Terwilliger, T C.]]

[[Category: dna-binding protein]]

[[Category: gene v]]

[[Category: mutant]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 05:02:~~43 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:37:33 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1vqh.jpg|left|200px]]<br /><applet load="1vqh" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1vqh.jpg|left|200px]]<br /><applet load="1vqh" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1vqh, resolution 1.8&Aring;" />
 '''GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY MET 47 (I47M)'''<br />
 ==Overview==
-The problem of rationally engineering protein molecules can be simplified, where effects of mutations on protein function are additive. Crystal, structures of single and double mutants in the hydrophobic core of gene V, protein indicate that structural and functional effects of core mutations, are additive when the regions structurally influenced by the mutations do, not substantially overlap. These regions of influence can provide a simple, basis for identifying sets of mutations that will show additive effects.
+The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects.
 ==About this Structure==
-VQH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacteriophage_f1 Bacteriophage f1]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VQH OCA].
+VQH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacteriophage_f1 Bacteriophage f1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQH OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Bacteriophage f1]]
 [[Category: Single protein]]
-[[Category: Skinner, M.M.]]
+[[Category: Skinner, M M.]]
-[[Category: Terwilliger, T.C.]]
+[[Category: Terwilliger, T C.]]
 [[Category: dna-binding protein]]
 [[Category: gene v]]
 [[Category: mutant]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 05:02:43 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:37:33 2008''