Conservation, Evolutionary: Difference between revisions
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Eric Martz (talk | contribs) →Locating Conserved Patches: added links to examples |
Eric Martz (talk | contribs) →Locating Variable Patches: added a new section with example on this page |
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==Locating Variable Patches== | ==Locating Variable Patches== | ||
In some cases, patches of highly variable (rapidly mutating) residues are also functional sites. These can also be identified with the [http://consurf.tau.ac.il ConSurf Server]. For example, mutations in influenza hemagglutinin help the virus to evade host defenses. Another example is the high allelic variability of the peptide-binding groove of [[Major Histocompatibility Complex Class I]]. That variability helps the grooves of the alleles within any individual to bind a wide range of peptides, hence enabling the T lymphocyte system to defend against a wide range of pathogens, including influenza virus. | In some cases, patches of highly variable (rapidly mutating) residues are also functional sites. These can also be identified with the [http://consurf.tau.ac.il ConSurf Server]. For example, mutations in influenza hemagglutinin help the virus to evade host defenses. Another example is the high allelic variability of the peptide-binding groove of [[Major Histocompatibility Complex Class I]]. That variability helps the grooves of the alleles within any individual to bind a wide range of peptides, hence enabling the T lymphocyte system to defend against a wide range of pathogens, including influenza virus. | ||
==Examples== | |||
<applet load='2vaa' size='400' frame='true' align='right' caption='Evolutionary conservation reported by ConSurfDB for Major Histocompatibility Class I alpha chain in [[2vaa]].'/> | |||
At right is the pattern of evolutionary conservation and variability reported by [http://consurfdb.tau.ac.il ConSurfDB] for the alpha chain of [[Major Histocompatibility Complex Class I]] (chain A of [[2vaa]]). Below are instructions for how to insert a ConSurf result into a Proteopedia scene. | |||
==Conservation for Domain Folding== | ==Conservation for Domain Folding== | ||
