3fl1: Difference between revisions

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'''Unreleased structure'''
{{Seed}}
[[Image:3fl1.jpg|left|200px]]


The entry 3fl1 is ON HOLD until Paper Publication
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{{STRUCTURE_3fl1|  PDB=3fl1  |  SCENE=  }}


Authors: Merlino, A., Russo Krauss, I., Perillo, M., Mattia, C.A., Ercole, C., Picone, D., Vergara, A., Sica, F.
===X-ray structure of the non covalent swapped form of the A19P/Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE===


Description: X-ray structure of the non covalent swapped form of the A19P/Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE


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{{ABSTRACT_PUBMED_19280639}}
 
==About this Structure==
3FL1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FL1 OCA].
 
==Reference==
<ref group="xtra">PMID:19280639</ref><ref group="xtra">PMID:15192098</ref><ref group="xtra">PMID:18164315</ref><ref group="xtra">PMID:8520472</ref><references group="xtra"/>
[[Category: Bos taurus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Ercole, C.]]
[[Category: Krauss, I Russo.]]
[[Category: Mattia, C A.]]
[[Category: Merlino, A.]]
[[Category: Perillo, M.]]
[[Category: Picone, D.]]
[[Category: Sica, F.]]
[[Category: Vergara, A.]]
[[Category: 3d-domain swapping]]
[[Category: Antitumor activity]]
[[Category: Bovine seminal ribonuclease]]
[[Category: Endonuclease]]
[[Category: Glycation]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Non-covalent dimer]]
[[Category: Nuclease]]
[[Category: Protein mutations and evolution]]
[[Category: Quaternary structure flexibility]]
[[Category: Secreted]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 12:31:21 2009''

Revision as of 10:31, 25 March 2009

File:3fl1.jpg

Template:STRUCTURE 3fl1

X-ray structure of the non covalent swapped form of the A19P/Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE

Template:ABSTRACT PUBMED 19280639

About this Structure

3FL1 is a 2 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

  1. Merlino A, Krauss IR, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F. Towards an antitumor form of bovine pancreatic ribonuclease: The crystal structure of three non-covalent dimeric mutants. Biopolymers. 2009 Mar 11. PMID:19280639 doi:10.1002/bip.21183
  2. Sica F, Di Fiore A, Merlino A, Mazzarella L. Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor. J Biol Chem. 2004 Aug 27;279(35):36753-60. Epub 2004 Jun 9. PMID:15192098 doi:https://dx.doi.org/10.1074/jbc.M405655200
  3. Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F. The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme. J Mol Biol. 2008 Feb 15;376(2):427-37. Epub 2007 Nov 12. PMID:18164315 doi:https://dx.doi.org/10.1016/j.jmb.2007.11.008
  4. Di Donato A, Cafaro V, Romeo I, D'Alessio G. Hints on the evolutionary design of a dimeric RNase with special bioactions. Protein Sci. 1995 Aug;4(8):1470-7. PMID:8520472 doi:https://dx.doi.org/10.1002/pro.5560040804

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