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| | [[Image:3d08.png|left|200px]] |
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| {{STRUCTURE_3d08| PDB=3d08 | SCENE= }} | | {{STRUCTURE_3d08| PDB=3d08 | SCENE= }} |
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| ===Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R=== | | ===Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R=== |
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| {{ABSTRACT_PUBMED_18996393}} | | {{ABSTRACT_PUBMED_18996393}} |
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| ==Disease== | | ==About this Structure== |
| Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Hepatocellular carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Histiocytoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Li-Fraumeni syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Multiple malignancy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Nasopharyngeal carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Osteosarcoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Thyroid carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]]
| | [[3d08]] is a 1 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D08 OCA]. |
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| ==About this Structure== | | ==See Also== |
| 3D08 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D08 OCA].
| | *[[P53|P53]] |
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| ==Reference== | | ==Reference== |
| <ref group="xtra">PMID:18996393</ref><references group="xtra"/> | | <ref group="xtra">PMID:018996393</ref><references group="xtra"/> |
| [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| [[Category: Frolow, F.]] | | [[Category: Frolow, F.]] |
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| [[Category: Shimon, L J.W.]] | | [[Category: Shimon, L J.W.]] |
| [[Category: Suad, O.]] | | [[Category: Suad, O.]] |
| [[Category: Acetylation]]
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| [[Category: Activator]] | | [[Category: Activator]] |
| [[Category: Alternative splicing]]
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| [[Category: Anti-oncogene]] | | [[Category: Anti-oncogene]] |
| [[Category: Apoptosis]] | | [[Category: Apoptosis]] |
| [[Category: Cell cycle]] | | [[Category: Cell cycle]] |
| [[Category: Covalent protein-rna linkage]] | | [[Category: Covalent protein-rna linkage]] |
| [[Category: Cytoplasm]]
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| [[Category: Disease mutation]] | | [[Category: Disease mutation]] |
| [[Category: Dna-binding]] | | [[Category: Dna-binding]] |
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| [[Category: P53]] | | [[Category: P53]] |
| [[Category: Phosphoprotein]] | | [[Category: Phosphoprotein]] |
| [[Category: Polymorphism]]
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| [[Category: Transcription]] | | [[Category: Transcription]] |
| [[Category: Transcription regulation]] | | [[Category: Transcription regulation]] |
| [[Category: Ubl conjugation]]
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| [[Category: Zinc]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:44:10 2009''
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