3dga: Difference between revisions
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[[Image:3dga.png|left|200px]] | |||
[[Image:3dga. | |||
{{STRUCTURE_3dga| PDB=3dga | SCENE= }} | {{STRUCTURE_3dga| PDB=3dga | SCENE= }} | ||
===Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP=== | ===Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP=== | ||
{{ABSTRACT_PUBMED_19146480}} | {{ABSTRACT_PUBMED_19146480}} | ||
==About this Structure== | ==About this Structure== | ||
[[3dga]] is a 4 chain structure of [[Dihydrofolate reductase]] and [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DGA OCA]. | |||
==See Also== | |||
*[[Dihydrofolate reductase|Dihydrofolate reductase]] | |||
*[[Thymidylate synthase|Thymidylate synthase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019146480</ref><references group="xtra"/> | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Anderson, K S.]] | [[Category: Anderson, K S.]] | ||
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[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 21:51, 26 July 2012
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP
Template:ABSTRACT PUBMED 19146480
About this Structure
3dga is a 4 chain structure of Dihydrofolate reductase and Thymidylate synthase with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
See Also
Reference
- Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS. Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. ACS Chem Biol. 2009 Jan 16;4(1):29-40. PMID:19146480 doi:10.1021/cb8002804