1w8p: Difference between revisions
New page: left|200px<br /> <applet load="1w8p" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w8p, resolution 2.08Å" /> '''STRUCTURAL PROPERTI... |
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==About this Structure== | ==About this Structure== | ||
1W8P is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and IPH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W8P OCA]]. | 1W8P is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and IPH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W8P OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: x-ray structure]] | [[Category: x-ray structure]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:59:41 2007'' | ||
Revision as of 11:54, 30 October 2007
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STRUCTURAL PROPERTIES OF THE B25TYR-NME-B26PHE INSULIN MUTANT.
Overview
The origins of differentiation of insulin from insulin-like growth factor, I (IGF-I) are still unknown. To address the problem of a structural and, biological switch from the mostly metabolic hormonal activity of insulin, to the predominant growth factor activities of IGF-I, an insulin analogue, with IGF-I-like structural features has been synthesized. Insulin residues, Phe(B25) and Tyr(B26) have been swapped with the IGF-I-like Tyr(24) and, Phe(25) sequence with a simultaneous methylation of the peptide nitrogen, of residue Phe(B26). These modifications were expected to introduce a, substantial kink in the main chain, as observed at residue Phe(25) in the, IGF-I crystal structure. These alterations should provide insight into the, structural origins of insulin-IGF-I structural and ... [(full description)]
About this Structure
1W8P is a [Protein complex] structure of sequences from [Homo sapiens] with ZN and IPH as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Toward the insulin-IGF-I intermediate structures: functional and structural properties of the [TyrB25NMePheB26] insulin mutant., Zakova L, Brynda J, Au-Alvarez O, Dodson EJ, Dodson GG, Whittingham JL, Brzozowski AM, Biochemistry. 2004 Dec 28;43(51):16293-300. PMID:15610023
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