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| ===A SMART Team Modeling Project from the CBM=== | | ===A SMART Team Modeling Project from the CBM=== |
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| ====This is a Test Series of scenes for <scene name='Anderson_Sandbox/Orig/1'>Lac-Y Permease</scene>====
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| To the right is an image representation of Lac-Y permese of E-coli. The Ligand is shown <scene name='Anderson_Sandbox/Ligand/3'>here</scene>, the Sidechains Participating in substrate binding are <scene name='Anderson_Sandbox/Sbu_binding_res/2'>here</scene>, and residues participating in proton translocation are here.
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| ====Function of Lactose Permease====
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| [[Image:(image info)|thumb|(Caption)]] | | [[Image:(image info)|thumb|(Caption)]] |
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| Lactose Permease is a transmembrane protein that facilitates the passage of lactose across the phospholipid bi-layer of the cell membrane. The transport mechanism used is an active co-transport that uses the inwardly directed H+ electrochemical gradient as its driving force. As a result, the lactose is accompanied from the periplasm to the cytoplasm of the cell by an H+ proton.<ref name="A. Green, et. al.">[http://www.jbc.org/cgi/content/full/275/30/23240]</ref>
| | <ref name="G. Gidwani">[http://www.faqs.org/nutrition/Kwa-Men/Lactose-Intolerance.html]</ref> |
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| Lactose is a disaccharide carbohydrate found primarily in mammalian milk. It is a disaccharide composed of the monosaccharides glucose and galactose. When lactose is ingested, it is brought into cells in the digestive system by the protein Lactose Permease. Here it is broken down into its monosaccharide subunits by the enzyme lactase so it may be used in the process of cellular respiration.<ref name="G. Gidwani">[http://www.faqs.org/nutrition/Kwa-Men/Lactose-Intolerance.html]</ref>
| | <applet load='1pv7' size='350' frame='true' align='right' caption='Image of Lac-y Permease' /> |
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| <applet load='1pv7' size='350' frame='true' align='right' caption='Image of Lac-y Permease' />
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| Highlighting the <scene name='Anderson_Sandbox/All_sulfurs/1'>Sulfur</scene> of the lactose permease protein.
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