User:Ralf Stephan/Sandbox 2: Difference between revisions
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== Available structures == | == Available structures == | ||
Membrane transport proteins are notoriously difficult to crystallize while in a working state. So, it's no surprise that there are preciously few structure data for ion channels. At the moment, the following α-type ion channels have been at least partly resolved: | Membrane transport proteins are notoriously difficult to crystallize while in a working state. So, it's no surprise that there are preciously few structure data for ion channels. At the moment, the following α-type ion channels have been at least partly resolved: | ||
* the [[voltage-dependent potassium channel]] from ''Rattus norvegicus'' ([[1exb]]) | * the [[voltage-dependent potassium channel]] from ''Rattus norvegicus'' ([[1exb]], [[2a79]], [[2r9r]]) | ||
* the [[voltage-dependent calcium channel]] from ''Rattus norvegicus'' (L-type: [[3bxk]], R-type: [[3bxl]]) | |||
* the [[voltage-gated potassium channel]] from ''Streptomyces lividans'' with the structures [[1bl8]], [[1k4c]], [[1k4d]] | * the [[voltage-gated potassium channel]] from ''Streptomyces lividans'' with the structures [[1bl8]], [[1k4c]], [[1k4d]] | ||
* the [[calcium-gated potassium channel mthK]] from ''Methanobacterium thermoautotrophicum'' ([[1lnq]]) | * the [[calcium-gated potassium channel mthK]] from ''Methanobacterium thermoautotrophicum'' ([[1lnq]]) | ||
* the [[voltage-gated potassium channel]] K<sub>v</sub>AP from ''Aeropyrum pernix'' ([[ | * the [[voltage-gated potassium channel]] K<sub>v</sub>AP from ''Aeropyrum pernix'' ([[1orq]], [[2a0l]]) | ||
* the [[voltage-gated calcium channel]] Ca<sub>V</sub> ([[1toh]], [[1toj]]) | * the [[voltage-gated calcium channel]] Ca<sub>V</sub> ([[1toh]], [[1toj]]) | ||
* the hyperpolarization-activated and cyclic nucleotide-gated K+ channel [[HCN]] from ''Mus musculus'' ([[1q3e]], [[1q43]], [[1q5o]]) | * the hyperpolarization-activated and cyclic nucleotide-gated K+ channel [[HCN]] from ''Mus musculus'' ([[1q3e]], [[1q43]], [[1q5o]], [[2ptm]], [[2q0a]], [[3bpz]]) | ||
* the [[ | * the [[inward rectifier potassium channels]] KirBac3.1 ([[1xl4]],[[1xl6]]) and Kir3.1 (Cyt. only: [[1n9p]], [[1uve]], [[1uvf]], [[1p7b]], [[2e4f]]) | ||
* the acid-sensitive (proton-gated) cation channel [[ASIC]] from ''Gallus gallus'' ([[2qts]]) | |||
* receptor channels like | * receptor channels like | ||
** the [[nicotinic acetylcholine-activated cation-selective channel]] from ''Torpedo marmorata'' ([[1oed]]) | ** the [[nicotinic acetylcholine-activated cation-selective channel]] from ''Torpedo marmorata'' ([[1oed]], [[2bg9]]) | ||
** the [[glutamate receptor]] 2 | ** the [[glutamate receptor]] 2 | ||
* a [[potassium channel]] from ''Burkholderia pseudomallei'' ([[1p7b]]) | * a [[potassium channel]] from ''Burkholderia pseudomallei'' ([[1p7b]]) | ||
* the [[ammonium transporter]] from ''Archaeoglobus fulgidus'' ([[2b2f]]) | * the [[ammonium transporter]] from ''Archaeoglobus fulgidus'' ([[2b2f]]) | ||
* the small-conductance [[mechanosensitive channel]] from ''E. coli'' K12 ([[2oau]]) | * the small-conductance [[mechanosensitive channel]] from ''E. coli'' K12 ([[2oau]]) | ||
* [[TRP channels]] ([[3e7k]]) | |||
* human [[phospholamban]] ([[1zll]]) | * human [[phospholamban]] ([[1zll]]) | ||
* the P7 [[viroporin]] of Hepatitis C virus ([[2k8j]]) | * the P7 [[viroporin]] of Hepatitis C virus ([[2k8j]]) | ||
* the [[M2 protein]] from Influenza A ([[2rlf]], [[3c9j]]) | |||
Additionally the following non-ribosomally synthesized channel proteins constitute ion channels, and have their structure resolved: | Additionally the following non-ribosomally synthesized channel proteins constitute ion channels, and have their structure resolved: | ||
