2dts: Difference between revisions

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{{Seed}}
[[Image:2dts.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_2dts", creates the "Structure Box" on the page.
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{{STRUCTURE_2dts|  PDB=2dts  |  SCENE=  }}  
{{STRUCTURE_2dts|  PDB=2dts  |  SCENE=  }}  
===Crystal Structure of the Defucosylated Fc Fragment from Human Immunoglobulin G1===
===Crystal Structure of the Defucosylated Fc Fragment from Human Immunoglobulin G1===
{{ABSTRACT_PUBMED_17368483}}


 
==Disease==
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[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.  
The line below this paragraph, {{ABSTRACT_PUBMED_17368483}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17368483 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17368483}}


==About this Structure==
==About this Structure==
2DTS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DTS OCA].  
[[2dts]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DTS OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:17368483</ref><references group="xtra"/>
<ref group="xtra">PMID:017368483</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kato, K.]]
[[Category: Kato, K.]]
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[[Category: Defucosylated glycoform]]
[[Category: Defucosylated glycoform]]
[[Category: Igg1]]
[[Category: Igg1]]
[[Category: Immune system]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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Retrieved from "https://proteopedia.org/2dts"