1tg2: Difference between revisions

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{{Seed}}
[[Image:1tg2.png|left|200px]]
[[Image:1tg2.png|left|200px]]


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{{STRUCTURE_1tg2|  PDB=1tg2  |  SCENE=  }}  
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===Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound===
===Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound===


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{{ABSTRACT_PUBMED_15557004}}
{{ABSTRACT_PUBMED_15557004}}


==Disease==
==About this Structure==
Known disease associated with this structure: Phenylketonuria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=612349 612349]], Hyperphenylalaninemia, mild OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=612349 612349]]
[[1tg2]] is a 1 chain structure of [[Phenylalanine hydroxylase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG2 OCA].


==About this Structure==
==See Also==
1TG2 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG2 OCA].
*[[Phenylalanine hydroxylase|Phenylalanine hydroxylase]]


==Reference==
==Reference==
<ref group="xtra">PMID:15557004</ref><references group="xtra"/>
<ref group="xtra">PMID:015557004</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylalanine 4-monooxygenase]]
[[Category: Phenylalanine 4-monooxygenase]]
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[[Category: Tyring, S.]]
[[Category: Tyring, S.]]
[[Category: Ugarte, M.]]
[[Category: Ugarte, M.]]
[[Category: Phenylalanine hydroxylase phenylketonuria mutant a313t in complex with cofactor analogue 7,8-dihydrobiopterin]]
[[Category: 8-dihydrobiopterin]]
 
[[Category: Oxidoreductase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:39:01 2009''
[[Category: Phenylalanine hydroxylase phenylketonuria mutant a313t in complex with cofactor analogue 7]]

Revision as of 10:55, 25 July 2012

File:1tg2.png

Template:STRUCTURE 1tg2

Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound

Template:ABSTRACT PUBMED 15557004

About this Structure

1tg2 is a 1 chain structure of Phenylalanine hydroxylase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Erlandsen H, Pey AL, Gamez A, Perez B, Desviat LR, Aguado C, Koch R, Surendran S, Tyring S, Matalon R, Scriver CR, Ugarte M, Martinez A, Stevens RC. Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16903-8. Epub 2004 Nov 19. PMID:15557004

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