1rr8: Difference between revisions

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{{Seed}}
[[Image:1rr8.png|left|200px]]
[[Image:1rr8.png|left|200px]]


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{{STRUCTURE_1rr8|  PDB=1rr8  |  SCENE=  }}  
{{STRUCTURE_1rr8|  PDB=1rr8  |  SCENE=  }}  


===Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I===
===Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I===


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{{ABSTRACT_PUBMED_15165849}}
{{ABSTRACT_PUBMED_15165849}}


==Disease==
==About this Structure==
Known disease associated with this structure: DNA topoisomerase I, camptothecin-resistant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126420 126420]]
[[1rr8]] is a 3 chain structure of [[Topoisomerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR8 OCA].


==About this Structure==
==See Also==
1RR8 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR8 OCA].
*[[Topoisomerase|Topoisomerase]]


==Reference==
==Reference==
<ref group="xtra">PMID:15165849</ref><references group="xtra"/>
<ref group="xtra">PMID:015165849</ref><references group="xtra"/>
[[Category: DNA topoisomerase]]
[[Category: DNA topoisomerase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Camptothecin]]
[[Category: Camptothecin]]
[[Category: Human topoisomerase i]]
[[Category: Human topoisomerase i]]
[[Category: Isomerase-dna complex]]
[[Category: Nucleic acid]]
[[Category: Nucleic acid]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Topotecan]]
[[Category: Topotecan]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:51:35 2009''

Revision as of 15:18, 25 July 2012

File:1rr8.png

Template:STRUCTURE 1rr8

Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I

Template:ABSTRACT PUBMED 15165849

About this Structure

1rr8 is a 3 chain structure of Topoisomerase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR. Mechanisms of camptothecin resistance by human topoisomerase I mutations. J Mol Biol. 2004 Jun 11;339(4):773-84. PMID:15165849 doi:https://dx.doi.org/10.1016/j.jmb.2004.03.077

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