2flb: Difference between revisions

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{{Seed}}
[[Image:2flb.png|left|200px]]
[[Image:2flb.png|left|200px]]


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{{STRUCTURE_2flb|  PDB=2flb  |  SCENE=  }}  
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===Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor===
===Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor===


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{{ABSTRACT_PUBMED_16487703}}
{{ABSTRACT_PUBMED_16487703}}
==Disease==
Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]]


==About this Structure==
==About this Structure==
2FLB is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLB OCA].  
[[2flb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLB OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:16487703</ref><references group="xtra"/>
<ref group="xtra">PMID:016487703</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Katz, B A.]]
[[Category: Katz, B A.]]
[[Category: Active site-directed]]
[[Category: Active site-directed]]
[[Category: Hydrolase-blood clotting complex]]
[[Category: Pyrazole-based inhibitor]]
[[Category: Pyrazole-based inhibitor]]
[[Category: Short hydrogen bond-mediated]]
[[Category: Short hydrogen bond-mediated]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:06:23 2009''

Revision as of 14:55, 7 January 2013

File:2flb.png

Template:STRUCTURE 2flb

Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor

Template:ABSTRACT PUBMED 16487703

About this Structure

2flb is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J. Discovery of novel hydroxy pyrazole based factor IXa inhibitor. Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:16487703 doi:10.1016/j.bmcl.2006.01.123

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