2atb: Difference between revisions
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{{STRUCTURE_2atb| PDB=2atb | SCENE= }} | {{STRUCTURE_2atb| PDB=2atb | SCENE= }} | ||
===Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT=== | ===Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/SCXA_LEIQH SCXA_LEIQH]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. | |||
==About this Structure== | ==About this Structure== | ||
[[2atb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus Leiurus quinquestriatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATB OCA]. | |||
[[Category: Leiurus quinquestriatus]] | [[Category: Leiurus quinquestriatus]] | ||
[[Category: Frolow, F.]] | [[Category: Frolow, F.]] | ||
| Line 23: | Line 15: | ||
[[Category: Muation]] | [[Category: Muation]] | ||
[[Category: Scorpion]] | [[Category: Scorpion]] | ||
[[Category: Toxin]] | |||
Revision as of 08:20, 23 April 2014
Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT
Function
[SCXA_LEIQH] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.
About this Structure
2atb is a 2 chain structure with sequence from Leiurus quinquestriatus. Full crystallographic information is available from OCA.
