1yd9: Difference between revisions

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[[Image:1yd9.gif|left|200px]]<br /><applet load="1yd9" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1yd9.gif|left|200px]]<br /><applet load="1yd9" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1yd9, resolution 1.6Å" />

'''1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.'''<br />

==Overview==

macroH2A is an H2A variant with a highly unusual structural organization., It has a C-terminal domain connected to the N-terminal histone domain by a, linker. Crystallographic and biochemical studies show that changes in the, L1 loop in the histone fold region of macroH2A impact the structure and, potentially the function of nucleosomes. The 1.6-A X-ray structure of the, nonhistone region reveals an alpha/beta fold which has previously been, found in a functionally diverse group of proteins. This region associates, with histone deacetylases and affects the acetylation status of, nucleosomes containing macroH2A. Thus, the unusual domain structure of, macroH2A integrates independent functions that are instrumental in, establishing a structurally and functionally unique chromatin domain.

macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.

==About this Structure==

1YD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with AU as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1YD9 OCA].

1YD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=AU:'>AU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YD9 OCA].

==Reference==

Line 17:

[[Category: Khochbin, S.]]

[[Category: Luger, K.]]

[[Category: Pehrson, J.R.]]

[[Category: Pehrson, J R.]]

[[Category: Perche, P.Y.]]

[[Category: Perche, P Y.]]

[[Category: Swamy, G.Y.S.K.]]

[[Category: Swamy, G Y.S K.]]

[[Category: AU]]

[[Category: a1pp domain]]

Line 25:

[[Category: macro-domain]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 06:41:~~51 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:04:10 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1yd9.gif|left|200px]]<br /><applet load="1yd9" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1yd9.gif|left|200px]]<br /><applet load="1yd9" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1yd9, resolution 1.6&Aring;" />
 '''1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.'''<br />
 ==Overview==
-macroH2A is an H2A variant with a highly unusual structural organization., It has a C-terminal domain connected to the N-terminal histone domain by a, linker. Crystallographic and biochemical studies show that changes in the, L1 loop in the histone fold region of macroH2A impact the structure and, potentially the function of nucleosomes. The 1.6-A X-ray structure of the, nonhistone region reveals an alpha/beta fold which has previously been, found in a functionally diverse group of proteins. This region associates, with histone deacetylases and affects the acetylation status of, nucleosomes containing macroH2A. Thus, the unusual domain structure of, macroH2A integrates independent functions that are instrumental in, establishing a structurally and functionally unique chromatin domain.
+macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.
 ==About this Structure==
-YD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with AU as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YD9 OCA].
+YD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=AU:'>AU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YD9 OCA].
 ==Reference==
@@ Line 17: / Line 17: @@
 [[Category: Khochbin, S.]]
 [[Category: Luger, K.]]
-[[Category: Pehrson, J.R.]]
+[[Category: Pehrson, J R.]]
-[[Category: Perche, P.Y.]]
+[[Category: Perche, P Y.]]
-[[Category: Swamy, G.Y.S.K.]]
+[[Category: Swamy, G Y.S K.]]
 [[Category: AU]]
 [[Category: a1pp domain]]
@@ Line 25: / Line 25: @@
 [[Category: macro-domain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:41:51 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:04:10 2008''