1yi8: Difference between revisions

Line 1:

[[Image:1yi8.gif|left|200px]]<br /><applet load="1yi8" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1yi8.gif|left|200px]]<br /><applet load="1yi8" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1yi8, resolution 2.1Å" />

'''Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp'''<br />

==Overview==

The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found, in Deinococcus radiodurans interacts with a nitric oxide synthase protein, that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges, transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal, structures of TrpRS II bound to tryptophan and 5-HRP reveal residue, substitutions that accommodate modified indoles. A class of auxiliary, bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard, amino acids.

The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found in Deinococcus radiodurans interacts with a nitric oxide synthase protein that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal structures of TrpRS II bound to tryptophan and 5-HRP reveal residue substitutions that accommodate modified indoles. A class of auxiliary bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard amino acids.

==About this Structure==

1YI8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1] with TRP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1YI8 OCA].

1YI8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1] with <scene name='pdbligand=TRP:'>TRP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YI8 OCA].

==Reference==

Line 13:

[[Category: Deinococcus radiodurans r1]]

[[Category: Single protein]]

[[Category: Buddha, M.R.]]

[[Category: Buddha, M R.]]

[[Category: Crane, B.R.]]

[[Category: Crane, B R.]]

[[Category: TRP]]

[[Category: auxiliary tryptophanyl trna synthetase]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 06:47:~~57 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:05:43 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1yi8.gif|left|200px]]<br /><applet load="1yi8" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1yi8.gif|left|200px]]<br /><applet load="1yi8" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1yi8, resolution 2.1&Aring;" />
 '''Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp'''<br />
 ==Overview==
-The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found, in Deinococcus radiodurans interacts with a nitric oxide synthase protein, that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges, transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal, structures of TrpRS II bound to tryptophan and 5-HRP reveal residue, substitutions that accommodate modified indoles. A class of auxiliary, bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard, amino acids.
+The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found in Deinococcus radiodurans interacts with a nitric oxide synthase protein that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal structures of TrpRS II bound to tryptophan and 5-HRP reveal residue substitutions that accommodate modified indoles. A class of auxiliary bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard amino acids.
 ==About this Structure==
-YI8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1] with TRP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YI8 OCA].
+YI8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1] with <scene name='pdbligand=TRP:'>TRP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YI8 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Deinococcus radiodurans r1]]
 [[Category: Single protein]]
-[[Category: Buddha, M.R.]]
+[[Category: Buddha, M R.]]
-[[Category: Crane, B.R.]]
+[[Category: Crane, B R.]]
 [[Category: TRP]]
 [[Category: auxiliary tryptophanyl trna synthetase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:47:57 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:05:43 2008''