1yub: Difference between revisions
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New page: left|200px<br /><applet load="1yub" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yub" /> '''SOLUTION STRUCTURE OF AN RRNA METHYLTRANSFER... |
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[[Image:1yub.jpg|left|200px]]<br /><applet load="1yub" size=" | [[Image:1yub.jpg|left|200px]]<br /><applet load="1yub" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1yub" /> | caption="1yub" /> | ||
'''SOLUTION STRUCTURE OF AN RRNA METHYLTRANSFERASE (ERMAM) THAT CONFERS MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN ANTIBIOTIC RESISTANCE, NMR, MINIMIZED AVERAGE STRUCTURE'''<br /> | '''SOLUTION STRUCTURE OF AN RRNA METHYLTRANSFERASE (ERMAM) THAT CONFERS MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN ANTIBIOTIC RESISTANCE, NMR, MINIMIZED AVERAGE STRUCTURE'''<br /> | ||
==Overview== | ==Overview== | ||
The Erm family of methyltransferases is responsible for the development of | The Erm family of methyltransferases is responsible for the development of resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics. These enzymes methylate an adenine of 23S ribosomal RNA that prevents the MLS antibiotics from binding to the ribosome and exhibiting their antibacterial activity. Here we describe the three-dimensional structure of an Erm family member, ErmAM, as determined by NMR spectroscopy. The catalytic domain of ErmAM is structurally similar to that found in other methyltransferases and consists of a seven-stranded beta-sheet flanked by alpha-helices and a small two-stranded beta-sheet. In contrast to the catalytic domain, the substrate binding domain is different from other methyltransferases and adopts a novel fold that consists of four alpha-helices. | ||
==About this Structure== | ==About this Structure== | ||
1YUB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Active as [http://en.wikipedia.org/wiki/rRNA_(adenine-N(6)-)-methyltransferase rRNA (adenine-N(6)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.48 2.1.1.48] Full crystallographic information is available from [http:// | 1YUB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Active as [http://en.wikipedia.org/wiki/rRNA_(adenine-N(6)-)-methyltransferase rRNA (adenine-N(6)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.48 2.1.1.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YUB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
[[Category: rRNA (adenine-N(6)-)-methyltransferase]] | [[Category: rRNA (adenine-N(6)-)-methyltransferase]] | ||
[[Category: Fesik, S | [[Category: Fesik, S W.]] | ||
[[Category: Holzman, T | [[Category: Holzman, T F.]] | ||
[[Category: Petros, A | [[Category: Petros, A M.]] | ||
[[Category: Schnuchel, A.]] | [[Category: Schnuchel, A.]] | ||
[[Category: Severin, J | [[Category: Severin, J M.]] | ||
[[Category: Walter, K.]] | [[Category: Walter, K.]] | ||
[[Category: Yu, L.]] | [[Category: Yu, L.]] | ||
| Line 29: | Line 29: | ||
[[Category: rrna]] | [[Category: rrna]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:09:09 2008'' | ||
