2ghv: Difference between revisions

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{{Seed}}
[[Image:2ghv.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_2ghv", creates the "Structure Box" on the page.
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{{STRUCTURE_2ghv|  PDB=2ghv  |  SCENE=  }}  
{{STRUCTURE_2ghv|  PDB=2ghv  |  SCENE=  }}  
===Crystal structure of SARS spike protein receptor binding domain===
===Crystal structure of SARS spike protein receptor binding domain===
{{ABSTRACT_PUBMED_16954221}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.  S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
The line below this paragraph, {{ABSTRACT_PUBMED_16954221}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16954221 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16954221}}


==About this Structure==
==About this Structure==
2GHV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHV OCA].  
[[2ghv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHV OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:16954221</ref><references group="xtra"/>
<ref group="xtra">PMID:016954221</ref><references group="xtra"/><references/>
[[Category: Human sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Farzan, M.]]
[[Category: Farzan, M.]]
[[Category: Hwang, W C.]]
[[Category: Hwang, W C.]]
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[[Category: S protein]]
[[Category: S protein]]
[[Category: Sar]]
[[Category: Sar]]
 
[[Category: Viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:16:03 2009''
Retrieved from "https://proteopedia.org/2ghv"