2b7d: Difference between revisions

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{{Seed}}
[[Image:2b7d.png|left|200px]]
[[Image:2b7d.png|left|200px]]


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{{STRUCTURE_2b7d|  PDB=2b7d  |  SCENE=  }}  
{{STRUCTURE_2b7d|  PDB=2b7d  |  SCENE=  }}  


===Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model===
===Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model===


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{{ABSTRACT_PUBMED_16412633}}
{{ABSTRACT_PUBMED_16412633}}


==Disease==
==About this Structure==
Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]]
[[2b7d]] is a 3 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7D OCA].


==About this Structure==
==See Also==
2B7D is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7D OCA].
*[[Factor VIIa|Factor VIIa]]


==Reference==
==Reference==
<ref group="xtra">PMID:16412633</ref><references group="xtra"/>
<ref group="xtra">PMID:016412633</ref><references group="xtra"/>
[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 46: Line 34:
[[Category: Young, W B.]]
[[Category: Young, W B.]]
[[Category: Yu, C.]]
[[Category: Yu, C.]]
[[Category: Blood clotting]]
[[Category: Short hydrogen bond]]
[[Category: Short hydrogen bond]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:10:00 2009''

Revision as of 23:57, 25 July 2012

File:2b7d.png

Template:STRUCTURE 2b7d

Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model

Template:ABSTRACT PUBMED 16412633

About this Structure

2b7d is a 3 chain structure of Factor VIIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Young WB, Mordenti J, Torkelson S, Shrader WD, Kolesnikov A, Rai R, Liu L, Hu H, Leahy EM, Green MJ, Sprengeler PA, Katz BA, Yu C, Janc JW, Elrod KC, Marzec UM, Hanson SR. Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2037-41. Epub 2006 Jan 18. PMID:16412633 doi:10.1016/j.bmcl.2005.12.059

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