1lrm: Difference between revisions

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{{Seed}}
[[Image:1lrm.png|left|200px]]
[[Image:1lrm.png|left|200px]]


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{{STRUCTURE_1lrm|  PDB=1lrm  |  SCENE=  }}  
{{STRUCTURE_1lrm|  PDB=1lrm  |  SCENE=  }}  


===Crystal structure of binary complex of the catalytic domain of human phenylalanine hydroxylase with dihydrobiopterin (BH2)===
===Crystal structure of binary complex of the catalytic domain of human phenylalanine hydroxylase with dihydrobiopterin (BH2)===


{{ABSTRACT_PUBMED_12019271}}


==Disease==
==About this Structure==
Known disease associated with this structure: Phenylketonuria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=612349 612349]], Hyperphenylalaninemia, mild OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=612349 612349]]
[[1lrm]] is a 1 chain structure of [[Phenylalanine hydroxylase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRM OCA].
 
==See Also==
*[[Phenylalanine hydroxylase|Phenylalanine hydroxylase]]


==About this Structure==
==Reference==
1LRM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRM OCA].
<ref group="xtra">PMID:012019271</ref><ref group="xtra">PMID:012126628</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylalanine 4-monooxygenase]]
[[Category: Phenylalanine 4-monooxygenase]]
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[[Category: Basket-arrangement]]
[[Category: Basket-arrangement]]
[[Category: Ferric iron]]
[[Category: Ferric iron]]
 
[[Category: Oxidoreductase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:15:37 2009''

Revision as of 01:25, 26 July 2012

File:1lrm.png

Template:STRUCTURE 1lrm

Crystal structure of binary complex of the catalytic domain of human phenylalanine hydroxylase with dihydrobiopterin (BH2)

Template:ABSTRACT PUBMED 12019271

About this Structure

1lrm is a 1 chain structure of Phenylalanine hydroxylase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Thoden JB, Henderson JM, Fridovich-Keil JL, Holden HM. Structural analysis of the Y299C mutant of Escherichia coli UDP-galactose 4-epimerase. Teaching an old dog new tricks. J Biol Chem. 2002 Jul 26;277(30):27528-34. Epub 2002 May 17. PMID:12019271 doi:10.1074/jbc.M204413200
  2. Andersen OA, Flatmark T, Hough E. Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation. J Mol Biol. 2002 Jul 26;320(5):1095-108. PMID:12126628

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