3dbs: Difference between revisions
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[[Image:3dbs.png|left|200px]] | [[Image:3dbs.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
[[3dbs]] is a 1 chain structure of [[Phosphoinositide 3-Kinases]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBS OCA]. | |||
==See Also== | |||
*[[Phosphoinositide 3-Kinases]] | |||
==Reference== | ==Reference== | ||
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[[Category: Pi3k gamma]] | [[Category: Pi3k gamma]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 08:20, 26 December 2010
Structure of PI3K gamma in complex with GDC0941
Template:ABSTRACT PUBMED 18754654
About this Structure
3dbs is a 1 chain structure of Phosphoinositide 3-Kinases with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Folkes AJ, Ahmadi K, Alderton WK, Alix S, Baker SJ, Box G, Chuckowree IS, Clarke PA, Depledge P, Eccles SA, Friedman LS, Hayes A, Hancox TC, Kugendradas A, Lensun L, Moore P, Olivero AG, Pang J, Patel S, Pergl-Wilson GH, Raynaud FI, Robson A, Saghir N, Salphati L, Sohal S, Ultsch MH, Valenti M, Wallweber HJ, Wan NC, Wiesmann C, Workman P, Zhyvoloup A, Zvelebil MJ, Shuttleworth SJ. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin -4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer . J Med Chem. 2008 Sep 25;51(18):5522-32. PMID:18754654 doi:10.1021/jm800295d
